UniProt Accession

 CD47_RAT; P97829; O35294 

Genbank Protein ID

 D87659; AF017437; BC085740 

Genbank Nucleotide ID

 BAA13420.1; AAB70273.1; AAH85740.1 

Protein Name

 Leukocyte surface antigen CD47 

Protein Synonyms/Alias

 Integrin-associated protein; IAP; CD47 

Gene Name

 Cd47 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
299	RTIQPPRKAVEEPLN	ubiquitination	[1]
309	EEPLNAFKESKGMMN	ubiquitination	[1]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T- cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection (By similarity). Plays an important role in memory formation and synaptic plasticity in the hippocampus. 

Sequence Annotation

 DOMAIN 19 125 Ig-like V-type.
 MOD_RES 19 19 Pyrrolidone carboxylic acid (Probable).
 CARBOHYD 34 34 N-linked (GlcNAc...) (Potential).
 CARBOHYD 61 61 N-linked (GlcNAc...) (Potential).
 CARBOHYD 73 73 N-linked (GlcNAc...) (Potential).
 CARBOHYD 80 80 N-linked (GlcNAc...) (Potential).
 CARBOHYD 109 109 N-linked (GlcNAc...) (Potential).
 CARBOHYD 204 204 N-linked (GlcNAc...) (Potential).
 DISULFID 33 261 By similarity.
 DISULFID 41 112 By similarity.  

Keyword

 Alternative splicing; Cell adhesion; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Integrin; Membrane; Pyrrolidone carboxylic acid; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 303 AA 

Protein Sequence

Gene Ontology

 GO:0070062; C:extracellular vesicular exosome; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; IEA:Compara.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
 GO:0016477; P:cell migration; IDA:RGD.
 GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
 GO:0008228; P:opsonization; IEA:Compara.
 GO:0050729; P:positive regulation of inflammatory response; IEA:Compara.
 GO:0050766; P:positive regulation of phagocytosis; IEA:Compara.
 GO:0009617; P:response to bacterium; IEA:Compara. 

Interpro

 IPR006704; CD47.
 IPR013147; CD47_TM.
 IPR013270; CD47_Vset.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold. 

Pfam

 PF04549; CD47
 PF08204; V-set_CD47 

SMART

  

PROSITE

 PS50835; IG_LIKE 

PRINTS