Tag | Content |
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CPLM ID | CPLM-012862 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | E3 ubiquitin-protein ligase UBR4 |
Protein Synonyms/Alias | N-recognin-4; Zinc finger UBR1-type protein 1 |
Gene Name | Ubr4 |
Gene Synonyms/Alias | Rbaf600; Zubr1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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1151 | AAETDPHKSSEITKN | ubiquitination | [1] |
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Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions (By similarity). |
Sequence Annotation | ZN_FING 1657 1730 UBR-type. MOD_RES 178 178 Phosphoserine (By similarity). MOD_RES 181 181 Phosphoserine (By similarity). MOD_RES 365 365 Phosphoserine (By similarity). MOD_RES 1085 1085 N6-acetyllysine (By similarity). MOD_RES 1403 1403 Phosphoserine. MOD_RES 2715 2715 Phosphothreonine (By similarity). MOD_RES 2719 2719 Phosphoserine (By similarity). MOD_RES 2722 2722 Phosphoserine (By similarity). MOD_RES 2724 2724 Phosphothreonine (By similarity). |
Keyword | Acetylation; Calmodulin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Ligase; Membrane; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 5194 AA |
Protein Sequence | MATSGGEEAA AAAPAPGAPA TGQDTTPGWE VAVRPLLSAS YSAFEMKELP QLVASVIESE 60 SEILHHEKQY EPFYSSFVAL STHYITTVCS LIPRNQLQSV AAACKVLIEF SLLRLENPDE 120 ACAVSQKHLI LLIKGLCTGC SRLDRTEIIT FTAMMKSAKL PQTVKTLSDV EDQKELASPV 180 SPELRQKEVQ MNFLNQLTSV FNPRTVPSPP ISPQALVEGE NDEQSSTEQA SAVKTKNVFI 240 AQNVASLQEL GGSEKLLRVC LNLPYFLRYI NRFQDAVVAN SFFIMPATVA DATAVRNGFH 300 SLVIDVTMAL DTLSLPVLEP LNPSRLQDVT VLSLSCLYAG VSVATCMAIL HVGSAQQVRT 360 GSTSSKEEDY ESDAATIVQK CLEIYDMIGQ AISSSRRAGG EHFQNFQLLG AWCLLNSLFL 420 ILHLSPTALA DKGKEKDPLA ALRVRDILSR TKEGVGSPKL GPGKGHQGFG VLSVILANHA 480 IKLLTSLFQD LQVEALHKGW ETDGPPAVLS IMAQSTSTQR VQRLIDSVPL TNLLLTLLST 540 SYRKACVLQR QRKGSMSSDA SASTDSNTYY EDDFSSTEED SSQDDDSEPI LGQWFEETIS 600 PSKEKAAPPP PPPPPPLESS PRVKSPSKQA SGEKGNILAS RKDPELFLGL ASNILNFITS 660 SMLNSRNNFI RNYLSVSLSE QHMATLASII KEVDKDGLKG SSDEDFAAAL YHFNHSLVTS 720 DLQSPNLQNT LLQQLGVAPL SSGPWPLYIH PQGLSVLSRL LLIWQHKAGA QGDPDVPECL 780 KVWDRFLTTM KQSALQGVVP SETEDLNIEH LQLLLLIFHS FSEKGRRAIL TTLVQSIQEL 840 SVNMEVQMRS APLILARLLL IFDYLLHQYS KAPVYLFEQV QHNLLSPPFG WASGSQDSSS 900 SSRRANIPLY HGFKEVEENW SKHFSSDAAP QPRFYCVLST EASEEDLNRL DSEACEVLFS 960 KLVKYDELYS SLTALLAAGS QLDTVKRKEN KNMTALEACA LQYYFLILWR ILGILPPSKT 1020 YMNQLAMNSP EMSECDILHT LRWSSRLRIS SYVSWIKDHL IRQGMRPEHA GSLVELAASK 1080 CSSVKYDVEI VEEYFARQIS SFCSIDCTTV LQLHEIPSLQ SIYTLDAAVS KVQVSLDEHF 1140 SKMAAETDPH KSSEITKNLL PATLQLIDTY ASFTRAYLLQ NLNEEGSTEK PSQEKLHGFA 1200 AVLAIGSSRC KANTLGPTLV QNLPSSVQSV CESWNNINTN EFPNIGSWRN AFANDTIPSE 1260 SYISAVQAAH LGTLCGQSLP LAASLKHALL SLVRLTGDLI VWSDEMNPAQ VIRALLPLLL 1320 ESSTESAAEI SSNSLERILG PAESDEFLAR VYEKLITGCY NILANHADPS SGLDESVLEE 1380 CLQYLEKQLE SSQARKAMEE FFSDGGELVQ IMMATANEDL SAKFCNRVLK FFTKLFQLTE 1440 KSPNPSLLHL CGSLAQLACV EPVRLQAWLT RMTTSPPKDS DQLEVIQENR QLLQLLTTYI 1500 VRENSQVGEG VCAVLLGTLT PMATDMLANG DGTGFPELMV VMATLASAGQ GAGHLQLHNA 1560 AVDWLGRCKK YLSQKNVVEK LNANVMHGKH VMVLECTCHI MSYLADVTNA LSQSNGQGPS 1620 HLSVDGEERA IEVDSDWVEE LAVEEEDSQA EDSDEDSLCN KLCTFTITQK EFMNQHWYHC 1680 HTCKMVDGVG VCTVCAKVCH KDHEISYAKY GSFFCDCGAK EDGSCLALVK RTPSSGMSST 1740 MKESAFQSEP RVSESLVRHA STSPADKAKV TISDGKVADE EKPKKSSLCR TVEGCREELQ 1800 NQANFSFAPL VLDMLNFLMD AIQTNFQQAS AVGSSSRAQQ ALSELHTVDK VVEMTDQLMV 1860 PTLGSQEGAF ENVRMNYSGD QGQTIRQLIS AHVLRRVAMC VLSSPHGRRQ HLAVSHEKGK 1920 ITVLQLSALL KQADSSKRKL TLTRLASAPV PFTVLSLTGN PCKEDYLAVC GLKDCHVLTF 1980 SSSGSVSDHL VLHPQLATGN FIIKAVWLPG SQTELAIVTA DFVKIYDLSV DALSPTFYFL 2040 LPSSKIRDVT FLFNEEGKNI IVIMSSAGYM YTQLMEEASS AQQGPFYVTN VLEINHEDLK 2100 DSNSQVAGGG VSVYYSHVLQ MLFFSYSQGK SFAATVSRST LEVLQLFPIN IKSSNGGSKT 2160 SPALCQWSEV MNHPGLVCCV QQTTGVPLVV MVKPDTFLIQ EIKTLPAKAK IQDMVAIRHT 2220 ACNEQQRTTM ILLCEDGSLR IYMANVENTS YWLQPSLQPS SVISIMKPVR KRKTATITAR 2280 TSSQVTFPID FFEHNQQLTD VEFGGNDLLQ VYNAQQIKHR LNSTGMYVAN TKPGGFTMEI 2340 SNNSSTMVMT GMRIQIGTQA IERAPSYIEI FGRTMQLNLS RSRWFDFPFT REEALQADRK 2400 LNLFIGASVD PAGVTMIDAV KIYGKTKEQF GWPDEPPEDF PSASVSSVCP PNLNQSNSTG 2460 DSDSAAPATT SGTVLERLVV SSLEALESCF AVGPIIEKER NKHAAQELAT LLLSLPAPAS 2520 VQQQSKSLLA SLHSSRSAYH SHKDQALLSK AVQCLNTSSK EGKDLDPEVF QRLVITARSI 2580 AVTRPNNLVH FTESKLPQME TEGAEEGKEP QKQVEGDGCS FITQLVNHFW KLHASKPKNA 2640 FLAPACLPGL THIEATVNAL VDIIHGYCTC ELDCINTASK IYMQMLLCPD PAVSFSCKQA 2700 LIRVLRPRNK RRHVTLPSSP RSNTPMGDKD DDDDDDADEK MQSSGIPDGG HIRQESQEQS 2760 EVDHGDFEMV SESMVLETAE NVNNGNPSPL EALLAGAEGF PPMLDIPPDA DDETMVELAI 2820 ALSLQQDQQG SSSSALGLQS LGLSGQAPSS SSLDAGTLSD TTASGVCACN SSVTLSAPAS 2880 DDEGSTAATD GSTLRTSPAD HGGSVGSESG GSAVDSVAGE HSVSGRSSAY GDATAEGHPA 2940 GPGSVSSSTG AISTTTGHQE GDGSEGEGEG EAEGDVHTSN RLHMVRLMLL ERLLQTLPQL 3000 RNVGGVRAIP YMQVILMLTT DLDGEDEKDK GALDNLLAQL IAELGMDKKD VSKKNERSAL 3060 NEVHLVVMRL LSVFMSRTKS GSKSSICESS SLISSATAAA LLSSGAVDYC LHVLKSLLEY 3120 WKGQQSEEEP VTTSQLLKPH TTSSPPDMSP FFLRQYVKGH AADVFEAYTQ LLTEMVLRLP 3180 YQIKKIADTS SRIPPPVFDH SWFYFLSEYL MIQQTPFVRR QVRKLLLFIC GSKEKYRQLR 3240 DLHTLDSHVR GIKKLLEEQG IFLRASVVTA SSGSALQYDT LISLMEHLKA CAEIAAQRTI 3300 NWQKFCIKDD SVLYFLLQVS FLVDEGVSPV LLQLLSCALC GSKVLAALAA STGSSSVASS 3360 APPAASSGQT TTQSKSSTKK SKKEKKEKEK EGESSGSQED QLCTALVNQL NRFADKETLI 3420 QFLRCFLLES NSSSVRWQAH CLTLHIYRNS NKAQQELLLD LMWSIWPELP AYGRKAAQFV 3480 DLLGYFSLKT AQTEKKLKEY SQKAVEILRT QNHILTNHPN SNIYNTLSGL VEFDGYYLES 3540 DPCLVCNNPE VPFCYIKLSS IKVDTRYTTT QQVVKLIGSH TISKVTVKIG DLKRTKMVRT 3600 INLYYNNRTV QAIVELKNKP ARWHKAKKVQ LTPGQTEVKI DLPLPIVASN LMIEFADFYE 3660 NYQASTETLQ CPRCSASVPA NPGVCGNCGE NVYQCHKCRS INYDEKDPFL CNACGFCKYA 3720 RFDFMLYAKP CCAVDPIENE EDRKKAVSNI NTLLDKADRV YHQLMGHRPQ LENLLCKVNE 3780 AAPEKPQEDS GTAGGISSTS ASVNRYILQL AQEYCGDCKN SFDELSKIIQ KVFASRKELL 3840 EYDLQQREAA TKSSRTSVQP TFTASQYRAL SVLGCGHTSS TKCYGCASAV TEHCITLLRA 3900 LATNPALRHI LVSQGLIREL FDYNLRRGAA AIREEVRQLM CLLTRDNPEA TQQMNDLIIG 3960 KVSTALKGHW ANPDLASSLQ YEMLLLTDSI SKEDSCWELR LRCALSLFLM AVNIKTPVVV 4020 ENITLMCLRI LQKLIKPPAP TSKKNKDVPV EALTTVKPYC NEIHAQAQLW LKRDPKASYE 4080 AWKKCLPIRG VDGNGKSPSK SELHRLYLTE KYVWRWKQFL SRRGKRTTPL DLKLGHNNWL 4140 RQVLFTPATQ AARQAACTIV EALASVPSRK QQVLDLLTSY LDELSVAGEC AAEYLALYQK 4200 LIASCHWKVY LAARGVLPYV GNLITKEIAR LLALEEATLS TDLQQGYALK SLTGLLSSFV 4260 EVESIKRHFK SRLVGTVLNG YLCLRKLVLQ RTKLIDETQD MLLEMLEDMT TGTESETKAF 4320 MAVCIETAKR YNLDDYRTPV FIFERLCSII YPEENEVTEF FVTLEKDPQQ EDFLQGRMPG 4380 NPYSSNEPGI GPLMRDIKNK ICQDCDLVAL LEDDSGMELL VNNKIISLDL PVAEVYKKVW 4440 CTTNEGEPMR IVYRMRGLLG DATEEFIESL DSTTDEEEDE EEVYRMAGVM AQCGGLQCML 4500 NRLAGVKDFK QGRHLLTVLL KLFSYCVKVK VNRQQLVKLE MNTLNVMLGT LNLALVAEQE 4560 SKDSGGAAVA EQVLSIMEII LDESNAEPLS EDKGNLLLTG DKDQLVMLLD QINSTFVRSN 4620 PSVLQGLLRI IPYLSFGEVE KMQILVERFK PYCSFDKYDE DHSGDDKVFL DCFCKIAAGI 4680 KNNSNGHQLK DLILQKGITQ SALDYMKKHI PSAKNLDADI WKKFLSRPAL PFILRLLRGL 4740 AMQHPATQVL IGTDSITSLH KLEQVSSDEG IGTLAENLLE ALREHPDVNK KIDAARRETR 4800 AEKKRMAMAM RQKALGTLGM TTNEKGQVVT KTALLKQMEE LIEEPGLTCC ICREGYKFQP 4860 TKVLGIYTFT KRVALEEMEN KPRKQQGYST VSHFNIVHYD CHLAAVRLAR GREEWESAAL 4920 QNANTKCNGL LPVWGPHVPE SAFATCLARH NTYLQECTGQ REPTYQLNIH DIKLLFLRFA 4980 MEQSFSADTG GGGRESNIHL IPYIIHTVLY VLNTTRATSR EEKNLQGFLE QPREKWTESA 5040 FDVDGPHYFT ILALHVLPPE QWKATRVEIL RRLLVASHAR AVAPGGATRL TDKAVKDYSA 5100 YRSSLLFWAL VDLIYNMFKK VPTSNTEGGW SCSLAEYIRH NDMPIYEAAD KALKTFQEEF 5160 MPVETFSEFL DAAGLLSEIT DPESFLKDLL NSVP 5194 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro. GO:0008270; F:zinc ion binding; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |