UniProt Accession

 MQSR_ECOLI; Q46865; Q2M9H8 

Genbank Protein ID

 U28377; U00096; AP009048 

Genbank Nucleotide ID

 AAA69190.1; AAC76058.1; BAE77078.1 

Protein Name

 mRNA interferase MqsR 

Protein Synonyms/Alias

 Endoribonuclease MqsR; Motility quorum-sensing regulator MqsR; Toxin MqsR 

Gene Name

 mqsR 

Gene Synonyms/Alias

 ygiU; b3022; JW2990 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
15	TRLSQVKKLVNAGQV	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed:19690171, PubMed:19943910) and translation- dependent (PubMed:20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed:19690171) but also after C in GC(A/U) sequences (PubMed:19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation; these effects are overcome by concomitant or subsequent expression of antitoxin MqsA. Overexpression also leads to a dramatic increase in tolerance to the antibiotic ofloxacin. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Endonuclease; Hydrolase; Nuclease; Quorum sensing; Reference proteome; Toxin; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 98 AA 

Protein Sequence

Gene Ontology

 GO:0004521; F:endoribonuclease activity; IDA:EcoCyc.
 GO:0017148; P:negative regulation of translation; IDA:EcoCyc.
 GO:0009372; P:quorum sensing; IEA:UniProtKB-KW.
 GO:0043488; P:regulation of mRNA stability; IDA:EcoCyc.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0044010; P:single-species biofilm formation; IMP:EcoCyc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

  

Pfam

  

SMART

  

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PRINTS