| Tag | Content |
|---|
| CPLM ID | CPLM-019819 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cyclic AMP-dependent transcription factor ATF-6 beta |
Protein Synonyms/Alias | cAMP-dependent transcription factor ATF-6 beta; Activating transcription factor 6 beta; ATF6-beta; Protein G13; cAMP response element-binding protein-related protein; Creb-rp; cAMP-responsive element-binding protein-like 1; Processed cyclic AMP-dependent transcription factor ATF-6 beta |
Gene Name | ATF6B |
Gene Synonyms/Alias | CREBL1; G13 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 305 | SLPRPERKSIVPAPM | ubiquitination | [1] | | 327 | EVDAKLLKRQQRMIK | ubiquitination | [1] | | 346 | ACQSRRKKKEYLQGL | ubiquitination | [1] | | 347 | CQSRRKKKEYLQGLE | ubiquitination | [1] | | 668 | TVPPSLRKQPSPTPG | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE. |
Sequence Annotation | DOMAIN 325 388 bZIP.
REGION 1 86 Transcription activation.
REGION 327 347 Basic motif (By similarity).
REGION 350 357 Leucine-zipper (By similarity).
CARBOHYD 476 476 N-linked (GlcNAc...) (Potential).
CARBOHYD 505 505 N-linked (GlcNAc...) (Potential).
CARBOHYD 610 610 N-linked (GlcNAc...) (Potential).
CARBOHYD 627 627 N-linked (GlcNAc...) (Potential).
CARBOHYD 676 676 N-linked (GlcNAc...) (Potential). |
Keyword | Activator; Alternative splicing; Complete proteome; DNA-binding; Endoplasmic reticulum; Glycoprotein; Membrane; Nucleus; Reference proteome; Signal-anchor; Transcription; Transcription regulation; Transmembrane; Transmembrane helix; Unfolded protein response. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 703 AA |
Protein Sequence | MAELMLLSEI ADPTRFFTDN LLSPEDWGLQ NSTLYSGLDE VAEEQTQLFR CPEQDVPFDG 60
SSLDVGMDVS PSEPPWELLP IFPDLQVKSE PSSPCSSSSL SSESSRLSTE PSSEALGVGE 120
VLHVKTESLA PPLCLLGDDP TSSFETVQIN VIPTSDDSSD VQTKIEPVSP CSSVNSEASL 180
LSADSSSQAF IGEEVLEVKT ESLSPSGCLL WDVPAPSLGA VQISMGPSLD GSSGKALPTR 240
KPPLQPKPVV LTTVPMPSRA VPPSTTVLLQ SLVQPPPVSP VVLIQGAIRV QPEGPAPSLP 300
RPERKSIVPA PMPGNSCPPE VDAKLLKRQQ RMIKNRESAC QSRRKKKEYL QGLEARLQAV 360
LADNQQLRRE NAALRRRLEA LLAENSELKL GSGNRKVVCI MVFLLFIAFN FGPVSISEPP 420
SAPISPRMNK GEPQPRRHLL GFSEQEPVQG VEPLQGSSQG PKEPQPSPTD QPSFSNLTAF 480
PGGAKELLLR DLDQLFLSSD CRHFNRTESL RLADELSGWV QRHQRGRRKI PQRAQERQKS 540
QPRKKSPPVK AVPIQPPGPP ERDSVGQLQL YRHPDRSQPA FLDAIDRRED TFYVVSFRRD 600
HLLLPAISHN KTSRPKMSLV MPAMAPNETL SGRGAPGDYE EMMQIECEVM DTRVIHIKTS 660
TVPPSLRKQP SPTPGNATGG PLPVSAASQA HQASHQPLYL NHP 703 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0005925; C:focal adhesion; IDA:HPA. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005730; C:nucleolus; IDA:HPA. GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc. GO:0006986; P:response to unfolded protein; IEA:UniProtKB-KW. GO:0007165; P:signal transduction; TAS:ProtInc. GO:0006351; P:transcription, DNA-dependent; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |