UniProt Accession

 ELOV4_HUMAN; Q9GZR5; B2R6B5; Q5TCS2; Q86YJ1; Q9H139 

Genbank Protein ID

 AF279654; AF279649; AF279650; AF279651; AF279652; AF279653; AF277094; AY037298; AK055277; AK312511; AL133475; AL132875; AL132875; AL133475; CH471051; BC038506 

Genbank Nucleotide ID

 AAG47669.1; AAG47669.1; AAG47669.1; AAG47669.1; AAG47669.1; AAG47669.1; AAG47668.1; AAK68639.1; BAB70895.1; BAG35412.1; CAI20320.1; CAI20320.1; CAI23374.1; CAI23374.1; EAW48701.1; AAH38506.1 

Protein Name

 Elongation of very long chain fatty acids protein 4 

Protein Synonyms/Alias

 3-keto acyl-CoA synthase ELOVL4; ELOVL fatty acid elongase 4; ELOVL FA elongase 4; Very-long-chain 3-oxoacyl-CoA synthase 4 

Gene Name

 ELOVL4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
35	WTWSIADKRVENWPL	ubiquitination	[1, 2, 3, 4]
280	PKKPKAGKTAMNGIS	ubiquitination	[3]
296	NGVSKSEKQLMIENG	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs). Elongates C24:0 and C26:0 acyl-CoAs. Seems to represent a photoreceptor- specific component of the fatty acid elongation system residing on the endoplasmic reticulum. May be implicated in docosahexaenoic acid (DHA) biosynthesis, which requires dietary consumption of the essential alpha-linolenic acid and a subsequent series of three elongation steps. May play a critical role in early brain and skin development. 

Sequence Annotation

 MOTIF 310 314 Di-lysine motif (Potential).
 CARBOHYD 20 20 N-linked (GlcNAc...).  

Keyword

 Complete proteome; Endoplasmic reticulum; Fatty acid biosynthesis; Fatty acid metabolism; Glycoprotein; Ichthyosis; Lipid biosynthesis; Lipid metabolism; Membrane; Mental retardation; Polymorphism; Reference proteome; Stargardt disease; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 314 AA 

Protein Sequence

Gene Ontology

 GO:0030176; C:integral to endoplasmic reticulum membrane; IDA:UniProtKB.
 GO:0008020; F:G-protein coupled photoreceptor activity; NAS:UniProtKB.
 GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
 GO:0019367; P:fatty acid elongation, saturated fatty acid; IDA:UniProtKB.
 GO:0035338; P:long-chain fatty-acyl-CoA biosynthetic process; TAS:Reactome.
 GO:0019432; P:triglyceride biosynthetic process; TAS:Reactome.
 GO:0042761; P:very long-chain fatty acid biosynthetic process; IDA:UniProtKB. 

Interpro

 IPR002076; GNS1_SUR4. 

Pfam

 PF01151; ELO 

SMART

  

PROSITE

 PS01188; ELO 

PRINTS