| Tag | Content |
|---|
| CPLM ID | CPLM-011127 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Monothiol glutaredoxin-3 |
Protein Synonyms/Alias | |
Gene Name | GRX3 |
Gene Synonyms/Alias | YDR098C; YD8557.05C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 203 | APVMLFMKGSPSEPK | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (By similarity). Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit (Probable). |
Sequence Annotation | DOMAIN 30 145 Thioredoxin.
DOMAIN 186 285 Glutaredoxin.
METAL 211 211 Iron-sulfur (2Fe-2S); shared with dimeric |
Keyword | 2Fe-2S; 3D-structure; Complete proteome; Iron; Iron-sulfur; Metal-binding; Redox-active center; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 285 AA |
Protein Sequence | MCSFQVPSAF SFNYTSYCYK RHQARYYTAA KLFQEMPVIE INDQEQFTYL TTTAAGDKLI 60
VLYFHTSWAE PCKALKQVFE AISNEPSNSN VSFLSIDADE NSEISELFEI SAVPYFIIIH 120
KGTILKELSG ADPKEYVSLL EDCKNSVNSG SSQTHTMENA NVNEGSHNDE DDDDEEEEEE 180
TEEQINARLT KLVNAAPVML FMKGSPSEPK CGFSRQLVGI LREHQVRFGF FDILRDESVR 240
QNLKKFSEWP TFPQLYINGE FQGGLDIIKE SLEEDPDFLQ HALQS 285 |
Gene Ontology | GO:0005829; C:cytosol; IDA:SGD. GO:0005634; C:nucleus; IDA:SGD. GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW. GO:0015036; F:disulfide oxidoreductase activity; IMP:SGD. GO:0009055; F:electron carrier activity; IEA:InterPro. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro. GO:0030036; P:actin cytoskeleton organization; IMP:SGD. GO:0045454; P:cell redox homeostasis; IEA:InterPro. GO:0006879; P:cellular iron ion homeostasis; IGI:SGD. GO:0034599; P:cellular response to oxidative stress; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |