| Tag | Content |
|---|
| CPLM ID | CPLM-011435 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | HDA1 complex subunit 2 |
Protein Synonyms/Alias | Histone deacetylase complex 1 subunit 2 |
Gene Name | HDA2 |
Gene Synonyms/Alias | PLO2; YDR295C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 655 | KNNVQVEKAAANGTR | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Required for activity of HDA1 histone deacetylase complex. The HDA1 histone deacetylase complex is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. |
Sequence Annotation | |
Keyword | Chromatin regulator; Coiled coil; Complete proteome; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 674 AA |
Protein Sequence | MSRKNSKKLK VYYLPVTLTQ FQKDLSEILI SLHAKSFKAS IIGEPQADAV NKPSGLPAGP 60
ETHPYPTLSQ RQLTYIFDSN IRAIANHPSL LVDHYMPRQL LRMEPTESSI AGSHKFQVLN 120
QLINSICFRD REGSPNEVIK CAIIAHSIKE LDLLEGLILG KKFRTKRLSG TSLYNEKHKF 180
PNLPTVDSTI NKDGTPNSVS STSSNSNSTS YTGYSKDDYD YSVKRNLKKR KINTDDWLFL 240
ATTKHLKHDQ YLLANYDIDM IISFDPMLEV ELPALQVLRN NANKDIPIIK LLVQNSPDHY 300
LLDSEIKNSS VKSSHLSNNG HVDDSQEYEE IKSSLLYFLQ ARNAPVNNCE IDYIKLVKCC 360
LEGKDCNNIL PVLDLITLDE ASKDSSDSGF WQPQLTKLQY SSTELPLWDG PLDIKTYQTE 420
LMHRAVIRLR DIQDEYAKGT VPLYEKRLNE TQRQNQLDEI KNSVGLTFKK KQEVEKSIND 480
SEKRLKHAMT ESTKLQNKIN HLLKNRQELE NFNKLPSNTI SSENHLEEGS ALADKLKEYI 540
DKNATLFNKL KELQQANAEK SKLNDELRSK YQIESSKAAE SAQTLKILQE SMKSLENEVN 600
GPLTKFSTES LKKELERLQN DFQSLKARNK FLKNYITLMN RQYDLKNKNN VQVEKAAANG 660
TRFRSTRSNT PNYT 674 |
Gene Ontology | GO:0005829; C:cytosol; IDA:SGD. GO:0070823; C:HDA1 complex; IDA:SGD. GO:0003682; F:chromatin binding; IDA:SGD. GO:0003677; F:DNA binding; IDA:SGD. GO:0031047; P:gene silencing by RNA; IMP:SGD. GO:0010978; P:gene silencing involved in chronological cell aging; IMP:SGD. GO:0016575; P:histone deacetylation; IMP:SGD. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:SGD. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
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PRINTS | |