| Tag | Content |
|---|
| CPLM ID | CPLM-023583 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Myotubularin-related protein 6 |
Protein Synonyms/Alias | |
Gene Name | MTMR6 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 115 | YAFSYNPKQNDSERL | ubiquitination | [1] | | 135 | IDLAEEYKRMGVPNS | ubiquitination | [1] | | 253 | MANRAAGKGYENEDN | ubiquitination | [1] | | 466 | PFLLEDQKKYLNPLY | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells. |
Sequence Annotation | DOMAIN 124 499 Myotubularin phosphatase.
REGION 248 251 Substrate binding (By similarity).
REGION 273 274 Substrate binding (By similarity).
REGION 336 342 Substrate binding (By similarity).
ACT_SITE 336 336 Phosphocysteine intermediate (By
BINDING 382 382 Substrate (By similarity).
MOD_RES 108 108 Phosphotyrosine (By similarity).
MOD_RES 561 561 Phosphoserine.
MOD_RES 589 589 Phosphoserine. |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Hydrolase; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 621 AA |
Protein Sequence | MEHIRTTKVE QVKLLDRFST SNKSLTGTLY LTATHLLFID SHQKETWILH HHIASVEKLA 60
LTTSGCPLVI QCKNFRTVHF IVPRERDCHD IYNSLLQLSK QAKYEDLYAF SYNPKQNDSE 120
RLQGWQLIDL AEEYKRMGVP NSHWQLSDAN RDYKICETYP RELYVPRIAS KPIIVGSSKF 180
RSKGRFPVLS YYHQDKEAAI CRCSQPLSGF SARCLEDEHL LQAISKANPV NRYMYVMDTR 240
PKLNAMANRA AGKGYENEDN YSNIRFQFVG IENIHVMRSS LQKLLEVNGT KGLSVNDFYS 300
GLESSGWLRH IKAVMDAAIF LAKAITVENA SVLVHCSDGW DRTSQVCSLG SLLLDSYYRT 360
IKGFMVLIEK DWISFGHKFS ERCGQLDGDP KEVSPVFTQF LECVWHLTEQ FPQAFEFSEA 420
FLLQIHEHIH SCQFGNFLGN CQKEREELKL KEKTYSLWPF LLEDQKKYLN PLYSSESHRF 480
TVLEPNTVSF NFKFWRNMYH QFDRTLHPRQ SVFNIIMNMN EQNKQLEKDI KDLESLTSYS 540
SFKIIVGQ 548 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell. GO:0015269; F:calcium-activated potassium channel activity; IDA:UniProtKB. GO:0004722; F:protein serine/threonine phosphatase activity; NAS:UniProtKB. GO:0004725; F:protein tyrosine phosphatase activity; NAS:UniProtKB. GO:0006661; P:phosphatidylinositol biosynthetic process; TAS:Reactome. GO:0044281; P:small molecule metabolic process; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |