CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018397
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphoenolpyruvate carboxylase 
Protein Synonyms/Alias
 PEPC; PEPCase 
Gene Name
 ppc 
Gene Synonyms/Alias
 STM4119 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
112ARTLRKLKNQPDLNDacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity). 
Sequence Annotation
 ACT_SITE 138 138 By similarity.
 ACT_SITE 546 546 By similarity.  
Keyword
 Allosteric enzyme; Carbon dioxide fixation; Complete proteome; Lyase; Magnesium; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 883 AA 
Protein Sequence
MNEQYSALRS NVSMLGKVLG ETIKDALGEH ILDRVETIRK LSKSSRAGNE ANRQELLTTL 60
QNLSNDELLP VARAFSQFLN LANTAEQYHS ISPKGEAASN PEVIARTLRK LKNQPDLNDA 120
TIKKAVESLS LELVLTAHPT EITRRTLIHK MGEINNCLKQ LDNTDIADYE RHQVMRRLRQ 180
LIAQSWHTDE IRKQRPSPVD EAKWGFAVVE NSLWQGVPNY LRELNEQLEE NLGYKLPVDF 240
VPVRFTSWMG GDRDGNPNVT ADITRHVLLL SRWKATDLFL KDIHVLVSEL SMVDATPELL 300
ALVGEEGASE PYRYLMKKLR ARLMATQSWL EARLKGEKLP KPAGLLTQNE QLWEPLYACY 360
QSLQACGMGI IANGELLDTL RRVKCFGVPL VRIDIRQEST RHTEALGEIT RYLGIGDYES 420
WSEADKQAFL IRELNSKRPL LPRNWEPSND TREVLETCKV IAEAPKGSIA AYVISMAKTP 480
SDVLAVHLLL KEAGIGFAMP VAPLFETLDD LNNADDVMTQ LLNIDWYRGL IQGKQMVMIG 540
YSDSAKDAGV MAASWAQYQA QDALIKTCEK AGIELTLFHG RGGSIGRGGA PAHAALLSQP 600
PGSLKGGLRV TEQGEMIRFK YGLPEVTVSS LSLYTSAILE ANLLPPPEPK DSWRHIMDEL 660
SVISCETYRG YVRENKDFVP YFRSATPEQE LGKLPLGSRP AKRRPTGGVE SLRAIPWIFA 720
WTQNRLMLPA WLGAGTALQK VVEDGKQSEL EAMCRDWPFF STRLGMLEMV FSKADLWLAD 780
YYDQRLVAKT LWPLGKELRD LLEEDIKVVL AIANDSHLMA DLPWIAESIQ LRNVYTDPLN 840
VLQAELLYRS RLTEEQGKSP DPRVEQALMV TIAGVAAGMR NTG 883 
Gene Ontology
 GO:0000287; F:magnesium ion binding; IEA:HAMAP.
 GO:0008964; F:phosphoenolpyruvate carboxylase activity; IEA:HAMAP.
 GO:0015977; P:carbon fixation; IEA:HAMAP.
 GO:0006107; P:oxaloacetate metabolic process; IEA:HAMAP.
 GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro. 
Interpro
 IPR021135; PEP_COase.
 IPR018129; PEP_COase_AS.
 IPR022805; PEP_COase_bac/pln-type.
 IPR015813; Pyrv/PenolPyrv_Kinase-like_dom. 
Pfam
 PF00311; PEPcase 
SMART
  
PROSITE
 PS00781; PEPCASE_1
 PS00393; PEPCASE_2 
PRINTS
 PR00150; PEPCARBXLASE.