CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040035
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Gamma-aminobutyric acid receptor subunit beta-3 
Protein Synonyms/Alias
  
Gene Name
 GABRB3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
99FVKETVDKLLKGYDIubiquitination[1]
102ETVDKLLKGYDIRLRubiquitination[1]
183DTYFLNDKKSFVHGVubiquitination[1]
184TYFLNDKKSFVHGVTubiquitination[1]
193FVHGVTVKNRMIRLHubiquitination[1]
254FYWRGGDKAVTGVERubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Cell junction; Cell membrane; Complete proteome; Ion channel; Ion transport; Membrane; Postsynaptic cell membrane; Reference proteome; Synapse; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 529 AA 
Protein Sequence
MQQLRRLWVL AAQPFCHLPE RCRLFFEIGG ISLAMPQCLL WICLAVWEAR GDLPFIAEND 60
AVLTVNWNAV KEHRTFYAIY ETSVNDPGNM SFVKETVDKL LKGYDIRLRP DFGGPPVCVG 120
MNIDIASIDM VSEVNMDYTL TMYFQQYWRD KRLAYSGIPL NLTLDNRVAD QLWVPDTYFL 180
NDKKSFVHGV TVKNRMIRLH PDGTVLYGLR ITTTAACMMD LRRYPLDEQN CTLEIESYGY 240
TTDDIEFYWR GGDKAVTGVE RIELPQFSIV EHRLVSRNVV FATGAYPRLS LSFRLKRNIG 300
YFILQTYMPS ILITILSWVS FWINYDASAA RVALGITTVL TMTTINTHLR ETLPKIPYVK 360
AIDMYLMGCF VFVFLALLEY AFVNYIFFGR GPQRQKKLAE KTAKAKNDRS KSESNRVDAH 420
GNILLTSLEV HNEMNEVSGG IGDTRNSAIS FDNSGIQYRK QSMPREGHGR FLGDRSLPHK 480
KTHLRRRSSQ LKIKIPDLTD VNAIDRWSRI VFPFTFSLFN LVYWLYYVN 529 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
 GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
 GO:0004890; F:GABA-A receptor activity; IEA:InterPro. 
Interpro
 IPR006028; GABAA_rcpt.
 IPR002289; GABAAb_rcpt.
 IPR006202; Neur_chan_lig-bd.
 IPR006201; Neur_channel.
 IPR006029; Neurotrans-gated_channel_TM.
 IPR018000; Neurotransmitter_ion_chnl_CS. 
Pfam
 PF02931; Neur_chan_LBD
 PF02932; Neur_chan_memb 
SMART
  
PROSITE
 PS00236; NEUROTR_ION_CHANNEL 
PRINTS
 PR01160; GABAARBETA.
 PR00253; GABAARECEPTR.
 PR00252; NRIONCHANNEL.