UniProt Accession

 LAMB3_HUMAN; Q13751; D3DT88; O14947; Q14733; Q9UJK4; Q9UJL1 

Genbank Protein ID

 L25541; U17760; U17745; U17746; U17747; U17748; U17749; U17750; U17751; U17752; U17753; U17754; U17755; U17756; U17757; U17758; U17759; D37766; AY035783; AL023754; AL023754; AL031316; AL031316; AL023754; CH471100; CH471100; BC075838 

Genbank Nucleotide ID

 AAA61834.1; AAC51352.1; AAC51352.1; AAC51352.1; AAC51352.1; AAC51352.1; AAC51352.1; AAC51352.1; AAC51352.1; AAC51352.1; AAC51352.1; AAC51352.1; AAC51352.1; AAC51352.1; AAC51352.1; AAC51352.1; AAC51352.1; BAA22263.1; AAK61364.1; CAA19297.2; CAI19989.1; CAI19989.1; CAI20062.1; CAI20062.1; EAW93448.1; EAW93449.1; AAH75838.1 

Protein Name

 Laminin subunit beta-3 

Protein Synonyms/Alias

 Epiligrin subunit bata; Kalinin B1 chain; Kalinin subunit beta; Laminin B1k chain; Laminin-5 subunit beta; Nicein subunit beta 

Gene Name

 LAMB3 

Gene Synonyms/Alias

 LAMNB1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
51	SSTCGLTKPETYCTQ	ubiquitination	[1]
65	QYGEWQMKCCKCDSR	ubiquitination	[1]
141	ERSSDFGKTWRVYQY	ubiquitination	[1, 2, 3]
188	NARLNGGKVQLNLMD	ubiquitination	[1, 2, 3]
207	IPATQSQKIQEVGEI	ubiquitination	[1, 2, 3]
402	VTGQCVCKEHVQGER	ubiquitination	[1]
414	GERCDLCKPGFTGLT	ubiquitination	[1]
705	RKREQFEKISSADPS	ubiquitination	[1, 2, 3]
766	GGGTGSPKLVALRLE	ubiquitination	[1, 2, 3]
786	DLTPTFNKLCGNSRQ	ubiquitination	[1]
953	DLVLSQTKQDIARAR	ubiquitination	[1, 2, 3, 4]
1027	QVLRPAEKLVTSMTK	ubiquitination	[1, 3]
1034	KLVTSMTKQLGDFWT	ubiquitination	[3]
1152	ADLTGLEKRVEQIRD	ubiquitination	[2, 3]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

 Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. 

Sequence Annotation

 DOMAIN 22 249 Laminin N-terminal.
 DOMAIN 250 315 Laminin EGF-like 1.
 DOMAIN 316 378 Laminin EGF-like 2.
 DOMAIN 379 430 Laminin EGF-like 3.
 DOMAIN 431 480 Laminin EGF-like 4.
 DOMAIN 481 533 Laminin EGF-like 5.
 DOMAIN 534 580 Laminin EGF-like 6.
 REGION 579 785 Domain II.
 REGION 786 816 Domain alpha.
 REGION 817 1170 Domain I.
 CARBOHYD 220 220 N-linked (GlcNAc...) (Potential).
 CARBOHYD 604 604 N-linked (GlcNAc...) (Potential).
 CARBOHYD 810 810 N-linked (GlcNAc...) (Potential).
 DISULFID 250 259 By similarity.
 DISULFID 252 279 By similarity.
 DISULFID 281 290 By similarity.
 DISULFID 293 313 By similarity.
 DISULFID 316 325 By similarity.
 DISULFID 318 343 By similarity.
 DISULFID 346 355 By similarity.
 DISULFID 358 376 By similarity.
 DISULFID 379 392 By similarity.
 DISULFID 381 399 By similarity.
 DISULFID 401 410 By similarity.
 DISULFID 413 428 By similarity.
 DISULFID 431 444 By similarity.
 DISULFID 433 451 By similarity.
 DISULFID 453 462 By similarity.
 DISULFID 465 478 By similarity.
 DISULFID 481 493 By similarity.
 DISULFID 483 500 By similarity.
 DISULFID 502 511 By similarity.
 DISULFID 519 531 By similarity.
 DISULFID 534 546 By similarity.
 DISULFID 536 553 By similarity.
 DISULFID 555 564 By similarity.
 DISULFID 567 578 By similarity.
 DISULFID 581 581 Interchain (Probable).
 DISULFID 584 584 Interchain (Probable).
 DISULFID 1171 1171 Interchain (Probable).  

Keyword

 Basement membrane; Cell adhesion; Coiled coil; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Epidermolysis bullosa; Extracellular matrix; Glycoprotein; Laminin EGF-like domain; Polymorphism; Reference proteome; Repeat; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1172 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; TAS:Reactome.
 GO:0005610; C:laminin-5 complex; IEA:Compara.
 GO:0005198; F:structural molecule activity; NAS:ProtInc.
 GO:0050873; P:brown fat cell differentiation; IEA:Compara.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
 GO:0008544; P:epidermis development; TAS:ProtInc.
 GO:0030198; P:extracellular matrix organization; TAS:Reactome.
 GO:0031581; P:hemidesmosome assembly; TAS:Reactome. 

Interpro

 IPR013032; EGF-like_CS.
 IPR002049; EGF_laminin.
 IPR008211; Laminin_N. 

Pfam

 PF00053; Laminin_EGF
 PF00055; Laminin_N 

SMART

 SM00180; EGF_Lam
 SM00136; LamNT 

PROSITE

 PS00022; EGF_1
 PS01186; EGF_2
 PS01248; EGF_LAM_1
 PS50027; EGF_LAM_2
 PS51117; LAMININ_NTER 

PRINTS