UniProt Accession

 MD2L1_MOUSE; Q9Z1B5; Q9JI53 

Genbank Protein ID

 U83902; AF261919; AK082934 

Genbank Nucleotide ID

 AAD09238.1; AAF69525.1; BAC38700.1 

Protein Name

 Mitotic spindle assembly checkpoint protein MAD2A 

Protein Synonyms/Alias

 Mitotic arrest deficient 2-like protein 1; MAD2-like protein 1 

Gene Name

 Mad2l1 

Gene Synonyms/Alias

 Mad2a 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
108	QFDIECDKTAKEEGV	acetylation	[1]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore- spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate (By similarity). 

Sequence Annotation

 DOMAIN 14 197 HORMA.
 REGION 195 205 Required for assuming the closed
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 170 170 Phosphoserine (By similarity).
 MOD_RES 195 195 Phosphoserine (By similarity).  

Keyword

 Acetylation; Cell cycle; Cell division; Centromere; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Kinetochore; Mitosis; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 205 AA 

Protein Sequence

Gene Ontology

 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0000776; C:kinetochore; IDA:MGI.
 GO:0072686; C:mitotic spindle; ISS:UniProtKB.
 GO:0005643; C:nuclear pore; IEA:Compara.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
 GO:0000922; C:spindle pole; IDA:MGI.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0000070; P:mitotic sister chromatid segregation; IMP:MGI.
 GO:0007094; P:mitotic spindle assembly checkpoint; IMP:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
 GO:0060564; P:negative regulation of mitotic anaphase-promoting complex activity; IEA:Compara.
 GO:0042177; P:negative regulation of protein catabolic process; ISS:UniProtKB.
 GO:0090267; P:positive regulation of mitotic cell cycle spindle assembly checkpoint; IMP:UniProtKB. 

Interpro

 IPR003511; HORMA_DNA-bd. 

Pfam

 PF02301; HORMA 

SMART

  

PROSITE

 PS50815; HORMA 

PRINTS