UniProt Accession

 HTL1_YEAST; Q9URQ5; D6VR30 

Genbank Protein ID

 AF162267; X59720; AY558371; BK006937 

Genbank Nucleotide ID

 AAD47275.1; CAC42974.1; AAS56697.1; DAA07499.1 

Protein Name

 High temperature lethal protein 1 

Protein Synonyms/Alias

 Chromatin structure-remodeling complex protein HTL1 

Gene Name

 HTL1 

Gene Synonyms/Alias

 DRT1; YCR020W-B 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
22	AYNNVTLKNLTAFQL	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Required for cell cycle progression through G2/M transition at temperatures higher than 33 degrees Celsius. Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. When associated with the RSC complex, may act coordinately with PKC1 to regulate G2/M transition. Together with LDB7, NPL6, RSC3, RSC30 components, defines a fungal-specific module within the RSC complex that plays a role in many cellular functions including the maintenance of cell wall integrity. 

Sequence Annotation

  

Keyword

 Cell cycle; Complete proteome; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 78 AA 

Protein Sequence

Gene Ontology

 GO:0016586; C:RSC complex; IDA:SGD.
 GO:0006338; P:chromatin remodeling; IC:SGD.
 GO:0000086; P:G2/M transition of mitotic cell cycle; IGI:UniProtKB.
 GO:0006337; P:nucleosome disassembly; IDA:SGD.
 GO:0051726; P:regulation of cell cycle; IGI:SGD.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006974; P:response to DNA damage stimulus; IMP:SGD.
 GO:0006368; P:transcription elongation from RNA polymerase II promoter; IDA:SGD. 

Interpro

  

Pfam

  

SMART

  

PROSITE

  

PRINTS