UniProt Accession

 CP2DA_MOUSE; P24456; Q64490 

Genbank Protein ID

 M24263; M27167; BC010989; BC057924 

Genbank Nucleotide ID

 AAA79023.1; AAA39878.1; AAH10989.1; AAH57924.1 

Protein Name

 Cytochrome P450 2D10 

Protein Synonyms/Alias

 CYPIID10; Cytochrome P450-16-alpha; Cytochrome P450CB; Testosterone 16-alpha hydroxylase 

Gene Name

 Cyp2d10 

Gene Synonyms/Alias

 Cyp2d-10 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
88	MVVINGLKAMKEVLL	ubiquitination	[1]
149	LRNFGLGKKSLEDWV	ubiquitination	[1]
150	RNFGLGKKSLEDWVT	ubiquitination	[1]
158	SLEDWVTKEARHLCD	acetylation	[2]
158	SLEDWVTKEARHLCD	ubiquitination	[1]
242	RIPGLPGKVFQGQKS	ubiquitination	[1]
284	AFLAEIEKVKGNAES	ubiquitination	[1]
286	LAEIEKVKGNAESSF	ubiquitination	[1]
394	VQDFLIPKGSILIPN	ubiquitination	[1]
407	PNMSSVLKDETVWEK	ubiquitination	[1]
414	KDETVWEKPLRFHPE	ubiquitination	[1]
432	DAQGHFVKPEAFMPF	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. 

Sequence Annotation

 METAL 446 446 Iron (heme axial ligand).  

Keyword

 Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 504 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0070330; F:aromatase activity; IEA:EC.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro. 

Interpro

 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I.
 IPR008069; Cyt_P450_E_grp-I_CYP2D-like. 

Pfam

 PF00067; p450 

SMART

  

PROSITE

 PS00086; CYTOCHROME_P450 

PRINTS

 PR00463; EP450I.
 PR01686; EP450ICYP2D.
 PR00385; P450.