CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042495
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Low-density lipoprotein receptor-related protein 1B 
Protein Synonyms/Alias
  
Gene Name
 LRP1B 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
700VIGLVLCKRKRRTKTubiquitination[1]
787ERKELLPKKIEIGIRubiquitination[2]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Disulfide bond; EGF-like domain; Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 798 AA 
Protein Sequence
XSNKKCIPMD LQCDRLDDCG DGSDEQGCRI APTEYTCEDN VNPCGDDAYC NQIKTSVFCR 60
CKPGFQRNMK NRQCEDLNEC LVFGTCSHQC INVEGSYKCV CDQNFQERNN TCIAEGSEDQ 120
VLYIANDTDI LGFIYPFNYS GDHQQISHIE HNSRITGMDV YYQRDMIIWS TQFNPGGIFY 180
KRIHGREKRQ ANSGLICPEF KRPRDIAVDW VAGNIYWTDH SRMHWFSYYT THWTSLRYSI 240
NVGQLNGPNC TRLLTNMAGE PYAIAVNPKR GMMYWTVVGD HSHIEEAAMD GTLRRILVQK 300
NLQRPTGLAV DYFSERIYWA DFELSIIGSV LYDGSNSVVS VSSKQGLLHP HRIDIFEDYI 360
YGAGPKNGVF RVQKFGHGSV EYLALNIDKT KGVLISHRYK QLDLPNPCLD LACEFLCLLN 420
PSGATCVCPE GKYLINGTCN DDSLLDDSCK LTCENGGRCI LNEKGDLRCH CWPSYSGERC 480
EVNHCSNYCQ NGGTCVPSVL GRPTCSCALG FTGPNCGKTV CEDFCQNGGT CIVTAGNQPY 540
CHCQPEYTGD RCQYYVCHHY CVNSESCTIG DDGSVECVCP TRYEGPKCEV DKCVRCHGGH 600
CIINKDSEDI FCNCTNGKIA SSCQLCDGYC YNGGTCQLDP ETNVPVCLCS TNWSGTQCER 660
PAPKSSKSDH ISTRSIAIIV PLVLLVTLIT TLVIGLVLCK RKRRTKTIRR QPIINGGINV 720
EIGNPSYNMY EVDHDHNDGG LLDPGFMIDP TKPTNYSNPV YAKLYMDGQN CRNSLGSVDE 780
RKELLPKKIE IGIRETVA 798 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005509; F:calcium ion binding; IEA:InterPro. 
Interpro
 IPR011042; 6-blade_b-propeller_TolB-like.
 IPR000742; EG-like_dom.
 IPR001881; EGF-like_Ca-bd.
 IPR013032; EGF-like_CS.
 IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
 IPR018097; EGF_Ca-bd_CS.
 IPR009030; Growth_fac_rcpt_N_dom.
 IPR000033; LDLR_classB_rpt.
 IPR002172; LDrepeatLR_classA_rpt. 
Pfam
 PF00008; EGF
 PF07645; EGF_CA
 PF00057; Ldl_recept_a
 PF00058; Ldl_recept_b 
SMART
 SM00181; EGF
 SM00179; EGF_CA
 SM00192; LDLa
 SM00135; LY 
PROSITE
 PS00010; ASX_HYDROXYL
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS01187; EGF_CA
 PS50068; LDLRA_2
 PS51120; LDLRB 
PRINTS