CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030797
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glutamate dehydrogenase 
Protein Synonyms/Alias
  
Gene Name
 GLUD1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
29DVSVDEVKALASLMTubiquitination[1, 2, 3, 4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 425 AA 
Protein Sequence
MTCPCDNASS VFLGFCIRYS TDVSVDEVKA LASLMTYKCA VVDVPFGGAK AGVKINPKNY 60
TDNELEKITR RFTMELAKKG FIGPGIDVPA PDMSTGEREM SWIADTYAST IGHYDINAHA 120
CVTGKPISQG GIHGRISATG RGVFHGIENF INEASYMSIL GMTPGFGDKT FVVQGFGNVG 180
LHSMRYLHRF GAKCIAVGES DGSIWNPDGI DPKELEDFKL QHGSILGFPK AKPYEGSILE 240
ADCDILIPAA SEKQLTKSNA PRVKAKIIAE GANGPTTPEA DKIFLERNIM VIPDLYLNAG 300
GVTVSYFEWL KNLNHVSYGR LTFKYERDSN YHLLMSVQES LERKFGKHGG TIPIVPTAEF 360
QDRISGASEK DIVHSGLAYT MERSARQIMR TAMKYNLGLD LRTAAYVNAI EKVFKVYNEA 420
GVTFT 425 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0016639; F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor; IEA:InterPro.
 GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro. 
Interpro
 IPR006095; Glu/Leu/Phe/Val_DH.
 IPR006096; Glu/Leu/Phe/Val_DH_C.
 IPR006097; Glu/Leu/Phe/Val_DH_dimer_dom.
 IPR014362; Glu_DH.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF00208; ELFV_dehydrog
 PF02812; ELFV_dehydrog_N 
SMART
 SM00839; ELFV_dehydrog 
PROSITE
 PS00074; GLFV_DEHYDROGENASE 
PRINTS
 PR00082; GLFDHDRGNASE.