CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001886
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glycoprotein hormones alpha chain 
Protein Synonyms/Alias
 Anterior pituitary glycoprotein hormones common subunit alpha; Choriogonadotropin alpha chain; Chorionic gonadotrophin subunit alpha; CG-alpha; Follicle-stimulating hormone alpha chain; FSH-alpha; Follitropin alpha chain; Luteinizing hormone alpha chain; LSH-alpha; Lutropin alpha chain; Thyroid-stimulating hormone alpha chain; TSH-alpha; Thyrotropin alpha chain 
Gene Name
 CGA 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
68YPTPLRSKKTMLVQKacetylation[1]
69PTPLRSKKTMLVQKNacetylation[1]
75KKTMLVQKNVTSESTacetylation[1]
99VTVMGGFKVENHTACacetylation[1]
Reference
 [1] A label selection approach to assess the role of individual amino groups in human choriogonadotropin receptor binding.
 Yadav SP, Brew K, Majercik MH, Puett D.
 J Biol Chem. 1994 Feb 11;269(6):3991-8. [PMID: 8307955] 
Functional Description
  
Sequence Annotation
 CARBOHYD 76 76 N-linked (GlcNAc...).
 CARBOHYD 102 102 N-linked (GlcNAc...).
 DISULFID 31 55
 DISULFID 34 84
 DISULFID 52 106
 DISULFID 56 108
 DISULFID 83 111  
Keyword
 3D-structure; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 116 AA 
Protein Sequence
MDYYRKYAAI FLVTLSVFLH VLHSAPDVQD CPECTLQENP FFSQPGAPIL QCMGCCFSRA 60
YPTPLRSKKT MLVQKNVTSE STCCVAKSYN RVTVMGGFKV ENHTACHCST CYYHKS 116 
Gene Ontology
 GO:0005576; C:extracellular region; TAS:Reactome.
 GO:0005179; F:hormone activity; TAS:ProtInc.
 GO:0007267; P:cell-cell signaling; TAS:ProtInc.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0032870; P:cellular response to hormone stimulus; IEA:Compara.
 GO:0048589; P:developmental growth; IEA:Compara.
 GO:0046884; P:follicle-stimulating hormone secretion; IEA:Compara.
 GO:0008406; P:gonad development; IEA:Compara.
 GO:0032275; P:luteinizing hormone secretion; IEA:Compara.
 GO:0046621; P:negative regulation of organ growth; IEA:Compara.
 GO:0016486; P:peptide hormone processing; TAS:Reactome.
 GO:0030335; P:positive regulation of cell migration; NAS:BHF-UCL.
 GO:0008284; P:positive regulation of cell proliferation; NAS:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; NAS:BHF-UCL.
 GO:0007165; P:signal transduction; TAS:ProtInc.
 GO:0030878; P:thyroid gland development; IEA:Compara.
 GO:0006590; P:thyroid hormone generation; IEA:Compara. 
Interpro
 IPR000476; Glyco_hormone. 
Pfam
 PF00236; Hormone_6 
SMART
 SM00067; GHA 
PROSITE
 PS00779; GLYCO_HORMONE_ALPHA_1
 PS00780; GLYCO_HORMONE_ALPHA_2
 PS50277; GLYCO_HORMONE_ALPHA_3 
PRINTS
 PR00274; GLYCOHORMONE.