UniProt Accession

 MED21_MOUSE; Q9CQ39; Q921I5 

Genbank Protein ID

 AK009742; AK012217; AK014428; AK019417; BC012286 

Genbank Nucleotide ID

 BAB26472.1; BAB28104.1; BAB29343.1; BAB31711.1; AAH12286.1 

Protein Name

 Mediator of RNA polymerase II transcription subunit 21 

Protein Synonyms/Alias

 Mediator complex subunit 21; RNA polymerase II holoenzyme component SRB7; RNAPII complex component SRB7 

Gene Name

 Med21 

Gene Synonyms/Alias

 Srb7; Surb7 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
131	DIAQSQLKTRSVTHS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 

Sequence Annotation

  

Keyword

 Activator; Complete proteome; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 144 AA 

Protein Sequence

Gene Ontology

 GO:0016592; C:mediator complex; IDA:MGI.
 GO:0003713; F:transcription coactivator activity; IEA:Compara.
 GO:0001824; P:blastocyst development; IMP:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0019827; P:stem cell maintenance; IMP:MGI.
 GO:0006366; P:transcription from RNA polymerase II promoter; IC:MGI. 

Interpro

 IPR021384; Mediator_Med21. 

Pfam

 PF11221; Med21 

SMART

  

PROSITE

  

PRINTS