| Tag | Content |
|---|
| CPLM ID | CPLM-018157 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Phosphoinositide 3-kinase regulatory subunit 4 |
Protein Synonyms/Alias | PI3-kinase regulatory subunit 4 |
Gene Name | Pik3r4 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 75 | KQELEELKIRLHSAQ | ubiquitination | [1] | | 89 | QNCLPFQKAAEKASE | ubiquitination | [1] | | 97 | AAEKASEKAAMLFRQ | ubiquitination | [1] | | 300 | MINREPEKRLEAEDY | ubiquitination | [1] | | 309 | LEAEDYLKQQRGNAF | ubiquitination | [1] | | 850 | KRARKHVKQDSNVNE | ubiquitination | [1] | | 1292 | SPSVSYYKKIIEGTE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Regulatory subunit of the PI3K complex. May regulate membrane trafficking late in the endocytic pathway (By similarity). |
Sequence Annotation | DOMAIN 26 324 Protein kinase.
REPEAT 413 450 HEAT 1.
REPEAT 458 495 HEAT 2.
REPEAT 572 610 HEAT 3.
REPEAT 612 648 HEAT 4.
REPEAT 991 1030 WD 1.
REPEAT 1040 1079 WD 2.
REPEAT 1093 1134 WD 3.
REPEAT 1139 1178 WD 4.
REPEAT 1182 1223 WD 5.
REPEAT 1237 1278 WD 6.
REPEAT 1327 1358 WD 7.
NP_BIND 32 40 ATP (By similarity).
ACT_SITE 148 148 Proton acceptor (By similarity).
BINDING 53 53 ATP (By similarity).
MOD_RES 808 808 Phosphoserine (By similarity).
MOD_RES 853 853 Phosphoserine (By similarity).
MOD_RES 865 865 Phosphoserine (By similarity).
MOD_RES 894 894 Phosphoserine.
MOD_RES 905 905 Phosphoserine.
MOD_RES 1316 1316 Phosphothreonine (By similarity).
LIPID 2 2 N-myristoyl glycine (By similarity). |
Keyword | ATP-binding; Complete proteome; Endosome; Kinase; Lipoprotein; Myristate; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1358 AA |
Protein Sequence | MGNQLAGIAP SQILSVESYF SDIHDFEYDK SLGSTRFFKV ARAKHREGLV VVKVFAIQDP 60
TLPLTSYKQE LEELKIRLHS AQNCLPFQKA AEKASEKAAM LFRQYVRDNL YDRISTRPFL 120
NNIEKRWIAF QILTAVDQAH KSGVRHGDIK TENVMVTSWN WVLLTDFASF KPTYLPEDNP 180
ADFNYFFDTS RRRTCYIAPE RFVDGGMFAT ELEYMRDPST PLVDLNSNQR ARGELKRAMD 240
IFSAGCVIAE LFTEGVPLFD LSQLLAYRNG HFFPEQVLNK IEDRSIRDLV TQMINREPEK 300
RLEAEDYLKQ QRGNAFPEIF YTFLQPYMAQ FAKETFLSAD ERILVIRKDL GNIIHNLCGH 360
DLPEKAEGES RASGLVVLVS VITSCLQTLK SCDSKLAALE LILHLAPRLS VEILLDRITP 420
YLLHFSNDSV PRVRAEALRT LTKVLALVQE VPRNDVNIYP EYILPGIAHL AQDDATIVRL 480
AYAENIALLA ETALRFLELV QLKTLNMENE PDNEEVDEAT RPNGDYDTEL QALHEMVQQK 540
VVTLLSDPEN IVKQTLMESG ITRLCVFFGR QKANDVLLSH MITFLNDKND WHLRGAFFDS 600
IVGVAAYVGW QSSSILKPLL QQGLSDAEEF VIVKALNALT CMCQLGLLQK PHVYEFASDI 660
APFLCHPNLW IRYGAVGFIT VVAHQISTAD VYCKLMPYLD PYITQPVIQI ERKLVLLSVL 720
KEPVSRSIFD YALRSKDIAS LFRHLHMRQK KRNGSLLDCP PPEDPTIAQL LKKLLSQGMT 780
EEEEDKLLAL KDFMMKSNRA KANAVDQSHL HDSSQKGVID LAALGITGRQ VDLVKTKQEP 840
DEKRARKHVK QDSNVNEEWK SMFGSLEPPN IPQALPKTSD HEVVQPGKPP RSESSAGICV 900
PLSTSPQVSE AAHIPSKKPV IPVVSSTVLP STYQIRITTC KTELQQLIQQ KREQCNAERI 960
AKQMMENAEW ESKPPPPGWR PKGLLVAHLH EHKSAVNRIR VSDEHLLFAT CSNDGTVKIW 1020
NSQKMEGKTT TTRSILTYSR IGGRVKTLTF CQGSHYLAIA SDNGAVQLLG IEASKLPKSP 1080
KIHPLQSRIL DQKEDGCVVD MHHFNSGAQS VLAYATVNGS LVGWDLRSSS NAWTLKHDLK 1140
SGLITSFAVD IHQCWLCIGT SSGAMACWDM RFQLPISSHC HPSRARIRRL SMHPLYQSWV 1200
IAAVQGNNEV SMWDMETGDR RLTLWASSAP PLSELQPSPH SVHGIYCSPA DGNPILLTAG 1260
SDMKIRFWDL VSPERSYVVA GSTGSPSVSY YKKIIEGTEV VQEIQNKQKV GPSDDTPRRG 1320
PESLPVGHHD IITDIATFQT TQGFIVTASR DGIVKVWK 1358 |
Gene Ontology | GO:0005770; C:late endosome; ISS:UniProtKB. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |