| Tag | Content |
|---|
| CPLM ID | CPLM-024242 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Aconitate hydratase |
Protein Synonyms/Alias | |
Gene Name | acnA |
Gene Synonyms/Alias | acn; MSMEG_3143; MSMEI_3062 |
Created Date | July 27, 2013 |
Organism | Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) |
NCBI Taxa ID | 246196 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 394 | DAKNAFRKDIHNYVE | pupylation | [1] |
|
Reference | [1] Expansion of the mycobacterial "PUPylome". Watrous J, Burns K, Liu WT, Patel A, Hook V, Bafna V, Barry CE 3rd, Bark S, Dorrestein PC. Mol Biosyst. 2010 Feb;6(2):376-85. [ PMID: 20094657] |
Functional Description | Catalyzes the isomerization of citrate to isocitrate via cis-aconitate (By similarity). |
Sequence Annotation | METAL 478 478 Iron-sulfur (4Fe-4S) (By similarity).
METAL 544 544 Iron-sulfur (4Fe-4S) (By similarity).
METAL 547 547 Iron-sulfur (4Fe-4S) (By similarity).
CROSSLNK 394 394 Isoglutamyl lysine isopeptide (Lys-Gln) |
Keyword | Complete proteome; Iron; Iron-sulfur; Isopeptide bond; Lyase; Metal-binding; Reference proteome; Tricarboxylic acid cycle; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 943 AA |
Protein Sequence | MSSENTGKSS LNSFGARDTL TVGDQSYEIY RLNAVPGTEK LPYSLKVLAE NLLRTEDGAN 60
ITKDHIEAIA NWDPNAEPSI EIQFTPARVI MQDFTGVPCI VDLATMREAV AALGGDPNKV 120
NPLAPAELVI DHSVILDVFG NASAFERNVE LEYERNAERY QFLRWGQGAF DDFKVVPPGT 180
GIVHQVNIEY LARTVMVRDG VAYPDTCVGT DSHTTMVNGL GVLGWGVGGI EAEAAMLGQP 240
VSMLIPRVVG FKLSGEIKPG VTATDVVLTV TDMLRRHGVV GKFVEFYGKG VAEVPLANRA 300
TLGNMSPEFG STAAIFPIDE ETINYLRLTG RTDEQLALVE AYAKAQGMWH DPEREPVFSE 360
YLELDLSTVV PSISGPKRPQ DRIELTDAKN AFRKDIHNYV EQNHPTPETK LDEAVEESFP 420
ASDPVSLSFA DDGAPDMRPS AANGATGRPT NPVLVHSEER GDFVLDHGAV VVAGITSCTN 480
TSNPSVMLGA ALLAKKAVEK GLTTKPWVKT NMAPGSQVVT DYYNKAGLWP YLEKLGYYLG 540
GYGCTTCIGN TGPLPEEISK AINDNDLAVT AVLSGNRNFE GRISPDVKMN YLASPPLVIA 600
YGIAGTMDFD FESDPLGQDS EGNDVFLRDI WPSAAEIEET IASSINREMF TESYADVFKG 660
DDRWRSLPTP EGDTFEWDPA STYVRKAPYF DGMPAEPEPV SDIKGARVLA LLGDSVTTDH 720
ISPAGAIKPG TPAAQYLDAN GVERKDYNSL GSRRGNHEVM IRGTFANIRL RNQLLDDVSG 780
GYTRDFTQPG GPQAFIYDAS ENYKKAGIPL VVLGGKEYGS GSSRDWAAKG TVLLGVKAVI 840
TESFERIHRS NLIGMGVIPL QFPAGESAAS LKLDGTETYD IEGIEELNSG KTPKTVHVTA 900
TKEDGSKVEF DAVVRIDTPG EADYYRNGGI LQYVLRNMLK SSK 943 |
Gene Ontology | GO:0052632; F:citrate hydro-lyase (cis-aconitate-forming) activity; IEA:EC. GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW. GO:0052633; F:isocitrate hydro-lyase (cis-aconitate-forming) activity; IEA:EC. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |