CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032344
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Myosin-6 
Protein Synonyms/Alias
  
Gene Name
 Myh6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
58VVSREGGKVTAETENubiquitination[1]
67TAETENGKTVTIKEDubiquitination[1]
72NGKTVTIKEDQVMQQubiquitination[1]
83VMQQNPPKFDKIEDMubiquitination[1]
184TGESGAGKTVNTKRVubiquitination[1]
206AAIGDRSKKENPNANubiquitination[2]
207AIGDRSKKENPNANKubiquitination[2]
214KENPNANKGTLEDQIubiquitination[1, 2]
235LEAFGNAKTVRNDNSubiquitination[1]
279SRVIFQLKAERNYHIubiquitination[1]
352EEKAGVYKLTGAIMHubiquitination[1]
364IMHYGNMKFKQKQREubiquitination[1]
368GNMKFKQKQREEQAEubiquitination[1]
384DGTEDADKSAYLMGLubiquitination[1]
398LNSADLLKGLCHPRVubiquitination[1]
451INATLETKQPRQYFIubiquitination[1]
560LYDNHLGKSNNFQKPubiquitination[1]
566GKSNNFQKPRNVKGKubiquitination[1]
635ADTGDSGKGKGGKKKubiquitination[1]
642KGKGGKKKGSSFQTVubiquitination[1]
659LHRENLNKLMTNLKTubiquitination[1]
665NKLMTNLKTTHPHFVubiquitination[1]
681CIIPNERKAPGVMDNubiquitination[1]
746DSRKGAEKLLGSLDIubiquitination[1]
759DIDHNQYKFGHTKVFubiquitination[1]
837PWMKLYFKIKPLLKSubiquitination[1]
839MKLYFKIKPLLKSAEubiquitination[1]
843FKIKPLLKSAETEKEubiquitination[1]
849LKSAETEKEMANMKEubiquitination[1]
855EKEMANMKEEFGRVKubiquitination[1]
867RVKDALEKSEARRKEubiquitination[1]
912ERCDQLIKNKIQLEAubiquitination[1]
914CDQLIKNKIQLEAKVubiquitination[1]
922IQLEAKVKEMTERLEubiquitination[1]
941MNAELTAKKRKLEDEubiquitination[1]
944ELTAKKRKLEDECSEubiquitination[1]
965DLELTLAKVEKEKHAubiquitination[1]
968LTLAKVEKEKHATENubiquitination[1]
978HATENKVKNLTEEMAubiquitination[1]
999AKLTKEKKALQEAHQubiquitination[1]
1018DLQAEEDKVNTLTKSubiquitination[1]
1024DKVNTLTKSKVKLEQubiquitination[1]
1028TLTKSKVKLEQQVDDubiquitination[1]
1044EGSLEQEKKVRMDLEubiquitination[1]
1056DLERAKRKLEGDLKLubiquitination[1]
1075IMDLENDKLQLEEKLubiquitination[1]
1081DKLQLEEKLKKKEFDubiquitination[1]
1095DISQQNSKIEDEQALubiquitination[1]
1108ALALQLQKKLKENQ*ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] A proteomics approach to identify the ubiquitinated proteins in mouse heart.
 Jeon HB, Choi ES, Yoon JH, Hwang JH, Chang JW, Lee EK, Choi HW, Park ZY, Yoo YJ.
 Biochem Biophys Res Commun. 2007 Jun 8;357(3):731-6. [PMID: 17451654] 
Functional Description
  
Sequence Annotation
  
Keyword
 Actin-binding; ATP-binding; Coiled coil; Complete proteome; Motor protein; Myosin; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1114 AA 
Protein Sequence
MTDAQMADFG AAAQYLRKSE KERLEAQTRP FDIRTECFVP DDKEEYVKAK VVSREGGKVT 60
AETENGKTVT IKEDQVMQQN PPKFDKIEDM AMLTFLHEPA VLYNLKERYA AWMIYTYSGL 120
FCVTVNPYKW LPVYNAEVVA AYRGKKRSEA PPHIFSISDN AYQYMLTDRE NQSILITGES 180
GAGKTVNTKR VIQYFASIAA IGDRSKKENP NANKGTLEDQ IIQANPALEA FGNAKTVRND 240
NSSRFGKFIR IHFGATGKLA SADIETYLLE KSRVIFQLKA ERNYHIFYQI LSNKKPELLD 300
MLLVTNNPYD YAFVSQGEVS VASIDDSEEL LATDSAFDVL SFTAEEKAGV YKLTGAIMHY 360
GNMKFKQKQR EEQAEPDGTE DADKSAYLMG LNSADLLKGL CHPRVKVGNE YVTKGQSVQQ 420
VYYSIGALAK SVYEKMFNWM VTRINATLET KQPRQYFIGV LDIAGFEIFD FNSFEQLCIN 480
FTNEKLQQFF NHHMFVLEQE EYKKEGIEWE FIDFGMDLQA CIDLIEKPMG IMSILEEECM 540
FPKASDMTFK AKLYDNHLGK SNNFQKPRNV KGKQEAHFSL VHYAGTVDYN IMGWLEKNKD 600
PLNETVVGLY QKSSLKLMAT LFSTYASADT GDSGKGKGGK KKGSSFQTVS ALHRENLNKL 660
MTNLKTTHPH FVRCIIPNER KAPGVMDNPL VMHQLRCNGV LEGIRICRKG FPNRILYGDF 720
RQRYRILNPA AIPEGQFIDS RKGAEKLLGS LDIDHNQYKF GHTKVFFKAG LLGLLEEMRD 780
ERLSRIITRI QAQARGQLMR IEFKKIVERR DALLVIQWNI RAFMGVKNWP WMKLYFKIKP 840
LLKSAETEKE MANMKEEFGR VKDALEKSEA RRKELEEKMV SLLQEKNDLQ LQVQAEQDNL 900
NDAEERCDQL IKNKIQLEAK VKEMTERLED EEEMNAELTA KKRKLEDECS ELKKDIDDLE 960
LTLAKVEKEK HATENKVKNL TEEMAGLDEI IAKLTKEKKA LQEAHQQALD DLQAEEDKVN 1020
TLTKSKVKLE QQVDDLEGSL EQEKKVRMDL ERAKRKLEGD LKLTQESIMD LENDKLQLEE 1080
KLKKKEFDIS QQNSKIEDEQ ALALQLQKKL KENQ 1114 
Gene Ontology
 GO:0005925; C:focal adhesion; IEA:Compara.
 GO:0016459; C:myosin complex; IDA:MGI.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0001725; C:stress fiber; IDA:MGI.
 GO:0030018; C:Z disc; IDA:MGI.
 GO:0030898; F:actin-dependent ATPase activity; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0000146; F:microfilament motor activity; IMP:MGI.
 GO:0008307; F:structural constituent of muscle; IEA:Compara.
 GO:0030048; P:actin filament-based movement; IMP:MGI.
 GO:0007512; P:adult heart development; IMP:MGI.
 GO:0055009; P:atrial cardiac muscle tissue morphogenesis; IEA:Compara.
 GO:0030509; P:BMP signaling pathway; IDA:MGI.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IDA:MGI.
 GO:0048739; P:cardiac muscle fiber development; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0030049; P:muscle filament sliding; IEA:Compara.
 GO:0043462; P:regulation of ATPase activity; IMP:MGI.
 GO:0008217; P:regulation of blood pressure; IMP:MGI.
 GO:0060420; P:regulation of heart growth; IDA:MGI.
 GO:0002027; P:regulation of heart rate; IMP:MGI.
 GO:0002026; P:regulation of the force of heart contraction; IMP:MGI.
 GO:0045214; P:sarcomere organization; IMP:MGI.
 GO:0006941; P:striated muscle contraction; IMP:MGI.
 GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IEA:Compara.
 GO:0007522; P:visceral muscle development; IMP:MGI. 
Interpro
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027401; Myosin-like_IQ_dom.
 IPR001609; Myosin_head_motor_dom.
 IPR004009; Myosin_N.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00063; Myosin_head
 PF02736; Myosin_N 
SMART
 SM00015; IQ
 SM00242; MYSc 
PROSITE
 PS50096; IQ 
PRINTS
 PR00193; MYOSINHEAVY.