CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044337
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Conserved oligomeric Golgi complex subunit 4 
Protein Synonyms/Alias
  
Gene Name
 COG4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
170HRYLCLDKSVIELSRubiquitination[1]
180IELSRQGKEGSMIDAubiquitination[1, 2]
190SMIDANLKLLQEAEQubiquitination[1]
212EKFAIATKEGDLPQVubiquitination[1, 2]
238LHEEGLRKFSEYLCKubiquitination[1]
324QVEKVVDKFIKQRDYubiquitination[1]
327KVVDKFIKQRDYHQQubiquitination[1]
350MRNSTTEKIEPRELDubiquitination[1, 2]
397SMASEEVKQEHQKCLubiquitination[1]
536QQGKFDTKGIESTDEubiquitination[1, 2, 3]
575TLESDCTKLFSQGIGubiquitination[1, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 789 AA 
Protein Sequence
MGTKMADLDS PPKLSGVQQP SEGVGGGRCS EISAELIRSL TELQELEAVY ERLCGEEKVV 60
ERELDALLEQ QNTIESKMVT LHRMGPNLQL IEGDAKQLAG MITFTCNLAE NVSSKVRQLD 120
LAKNRLYQAI QRADDILDLK FCMDGVQTAL RSEDYEQAAA HTHRYLCLDK SVIELSRQGK 180
EGSMIDANLK LLQEAEQRLK AIVAEKFAIA TKEGDLPQVE RFFKIFPLLG LHEEGLRKFS 240
EYLCKQVASK AEENLLMVLG TDMSDRRAAV IFADTLTLLF EGIARIVETH QPIVETYYGP 300
GRLYTLIKYL QVECDRQVEK VVDKFIKQRD YHQQFRHVQN NLMRNSTTEK IEPRELDPIL 360
TEVTLMNARS ELYLRFLKKR ISSDFEVGDS MASEEVKQEH QKCLDKLLNN CLLSCTMQEL 420
IGLYVTMEEY FMRETVNKAV ALDTYEKGQL TSSMVDDVFY IVKKCIGRAL SSSSIDCLCA 480
MINLATTELE SDFRDVLCNK LRMGFPATTF QDIQRGVTSA VNIMHSSLQQ GKFDTKGIES 540
TDEAKMSFLV TLNNVEVCSE NISTLKKTLE SDCTKLFSQG IGGEQAQAKF DSCLSDLAAV 600
SNKFRDLLQE GLTELNSTAI KPQVQPWINS FFSVSHNIEE EEFNDYEAND PWVQQFILNL 660
EQQMAEFKAS LSPVIYDSLT GLMTSLVAVE LEKVVLKSTF NRLGGLQFDK ELRSLIAYLT 720
TVTTWTIRDK FARLSQMATI LNLERVTEIL DYWGPNSGPL TWRLTPAEVR QVLALRIDFR 780
SEDIKRLRL 789 
Gene Ontology
  
Interpro
 IPR013167; COG_su4. 
Pfam
 PF08318; COG4 
SMART
 SM00762; Cog4 
PROSITE
  
PRINTS