CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031922
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Renin receptor 
Protein Synonyms/Alias
 cDNA FLJ59846, highly similar to Renin receptor 
Gene Name
 ATP6AP2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
127SRHKHLAKDHSPDLYubiquitination[1]
146AGLDEIGKRYGEDSEubiquitination[1, 2, 3, 4]
160EQFRDASKILVDALQubiquitination[1, 2, 4, 5]
206TRTILEAKQAKNPASubiquitination[2, 4]
268IYRMTNQKIRMD***ubiquitination[2]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Receptor; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 272 AA 
Protein Sequence
MAVFVVLLAL VAGVLGNEFS ILKSPGSVVF RNGNWPIPGE RIPDVAALSM GFSVKEDLSW 60
PGLAVGNLFH RPRATVMVMV KGVNKLALPP GSVISYPLEN VDLLFLSELQ VLHDISSLLS 120
RHKHLAKDHS PDLYSLELAG LDEIGKRYGE DSEQFRDASK ILVDALQKFA DDMYSLYGGN 180
AVVELVTVKS FDTSLIRKTR TILEAKQAKN PASPYNLAYK YNFEYSVVFN MVLWIMIALA 240
LAVIITSYNI WNMDPGYDSI IYRMTNQKIR MD 272 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0004872; F:receptor activity; IEA:InterPro. 
Interpro
 IPR012493; Renin_rcpt. 
Pfam
 PF07850; Renin_r 
SMART
  
PROSITE
  
PRINTS