CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005229
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 CDP-diacylglycerol--serine O-phosphatidyltransferase 
Protein Synonyms/Alias
 Phosphatidylserine synthase 
Gene Name
 pssA 
Gene Synonyms/Alias
 pss; b2585; JW2569 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
9LSKFKRNKHQQHLAQacetylation[1, 2]
43FRETLLEKIASAKQRacetylation[2]
165VYLHQHDKYRYDRYHacetylation[2]
212RPKSPEIKNDIRLFRacetylation[2]
248TPLVGLGKSSLLNKTacetylation[2]
254GKSSLLNKTIFHLMPacetylation[1, 2]
350QLVVRLWKDDDNTYHacetylation[2]
359DDNTYHLKGMWVDDKacetylation[2]
403ELAPQREKELELIREacetylation[2]
430SIADYPVKVRKLIRRacetylation[2]
Reference
 [1] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [2] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
  
Sequence Annotation
 DOMAIN 133 159 PLD phosphodiesterase 1.
 DOMAIN 352 379 PLD phosphodiesterase 2.
 REGION 119 154 Hydrophobic.
 REGION 239 284 Hydrophobic.  
Keyword
 Cell inner membrane; Cell membrane; Complete proteome; Cytoplasm; Direct protein sequencing; Lipid biosynthesis; Lipid metabolism; Membrane; Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome; Repeat; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 451 AA 
Protein Sequence
MLSKFKRNKH QQHLAQLPKI SQSVDDVDFF YAPADFRETL LEKIASAKQR ICIVALYLEQ 60
DDGGKGILNA LYEAKRQRPE LDVRVLVDWH RAQRGRIGAA ASNTNADWYC RMAQENPGVD 120
VPVYGVPINT REALGVLHFK GFIIDDSVLY SGASLNDVYL HQHDKYRYDR YHLIRNRKMS 180
DIMFEWVTQN IMNGRGVNRL DDVNRPKSPE IKNDIRLFRQ ELRDAAYHFQ GDADNDQLSV 240
TPLVGLGKSS LLNKTIFHLM PCAEQKLTIC TPYFNLPAIL VRNIIQLLRE GKKVEIIVGD 300
KTANDFYIPE DEPFKIIGAL PYLYEINLRR FLSRLQYYVN TDQLVVRLWK DDDNTYHLKG 360
MWVDDKWMLI TGNNLNPRAW RLDLENAILI HDPQLELAPQ REKELELIRE HTTIVKHYRD 420
LQSIADYPVK VRKLIRRLRR IRIDRLISRI L 451 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0003882; F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity; IEA:EC.
 GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW. 
Interpro
 IPR016270; PLipase-D_PtdSer-synthase-type.
 IPR001736; PLipase_D/transphosphatidylase. 
Pfam
 PF00614; PLDc 
SMART
 SM00155; PLDc 
PROSITE
 PS50035; PLD 
PRINTS