| Tag | Content |
|---|
| CPLM ID | CPLM-008782 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ribosome assembly protein 1 |
Protein Synonyms/Alias | EF-2-like GTPase; Elongation factor-like 1 |
Gene Name | RIA1 |
Gene Synonyms/Alias | EFL1; YNL163C; N1718 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 475 | KNTSDLYKRAKDTVM | ubiquitination | [1] |
|
Reference | [1] A perturbed ubiquitin landscape distinguishes between ubiquitin in trafficking and in proteolysis. Ziv I, Matiuhin Y, Kirkpatrick DS, Erpapazoglou Z, Leon S, Pantazopoulou M, Kim W, Gygi SP, Haguenauer-Tsapis R, Reis N, Glickman MH, Kleifeld O. Mol Cell Proteomics. 2011 May;10(5):M111.009753. [ PMID: 21427232] |
Functional Description | GTPase involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SDO1, may trigger the GTP-dependent release of TIF6 from 60S pre- ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating TIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Inhibits GTPase activity of ribosome-bound EF-2. |
Sequence Annotation | NP_BIND 26 33 GTP (By similarity).
NP_BIND 102 106 GTP (By similarity).
NP_BIND 156 159 GTP (By similarity).
MOD_RES 431 431 Phosphoserine. |
Keyword | Complete proteome; Cytoplasm; GTP-binding; Hydrolase; Nucleotide-binding; Phosphoprotein; Reference proteome; Ribosome biogenesis. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1110 AA |
Protein Sequence | MPRVESETYK RLQNDPSCIR NICIVAHVDH GKTSLSDSLL ASNGIISQRL AGKIRFLDAR 60
PDEQLRGITM ESSAISLYFR VLRKQEGSDE PLVSEHLVNL IDSPGHIDFS SEVSAASRLC 120
DGAVVLVDVV EGVCSQTVTV LRQCWTEKLK PILVLNKIDR LITELQLTPQ EAYIHLSKVI 180
EQVNSVIGSF FANERQLDDL FWREQLEKNE NAEYIEKDDS GIYFNPTDNN VIFASAIDGW 240
GFNIGQLAKF YEQKLGAKRE NLQKVLWGDF YMDPKTKKII NNKGLKGRSL KPLFTSLILE 300
NIWKIYQNII TSRDSEMVEK IAKTLNIKLL ARDLRSKDDK QLLRTIMGQW LPVSTAVLLT 360
VIEKLPSPLE SQTDRLNTIL VSESDTAAMD PRLLKAMKTC DKEGPVSAYV SKMLSIPREE 420
LPVESKRIAS SDELMERSRK AREEALNAAK HAGMVENMAM MDLNDNSKNT SDLYKRAKDT 480
VMTPEVGEQT KPKPSRNNDV FCVVSEPSSA LDLEFEYEGE DDSDSQDNFG LDFVPTDIDP 540
NDPLSSMFEY EEEDPLLESI KQISEDVNDE VDDIFDEKEE CLVAFARIYS GTLRVGQEIS 600
VLGPKYDPKC PEEHIETAII THLYLFMGKE LVPLDVCPSG NIVGIRGLAG KVLKSGTLIE 660
KGVQGVNLAG VNFHFTPIVR VAVEPANPVE MSKLVRGLKL LDQADPCVHT YVENTGEHIL 720
CTAGELHLER CLKDLTERFA GIEITHSEPA IPYRETFLSA SDMNPPQNSQ LGRGVHELLL 780
SQYKITFRTF PLSGKVTDFL SQHQNSIKNI LKTSTSSMDP VIESTGSSFL DKKSLLVAFE 840
EVINQEEKSR ELLSGFKVKL AGFGPSRVGC NILLSQDNLL GSLFEGTPAA FEYSDSIKNG 900
FQLAVSEGPL ANEPVQGMCV LVESVHKMSQ DEIESIEDPR YQQHIVDLSG RLITSTRDAI 960
HEAFLDWSPR IMWAIYSCDI QTSVDVLGKV YAVILQRHGK IISEEMKEGT PFFQIEAHVP 1020
VVEAFGLSED IRKRTSGAAQ PQLVFSGFEC IDLDPFWVPT TEEELEELGD TADRENIARK 1080
HMNAIRRRKG LFIEEKVVEN AEKQRTLKKN 1110 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |