| Tag | Content |
|---|
| CPLM ID | CPLM-016600 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Apoptosis-inducing factor 2 |
Protein Synonyms/Alias | Apoptosis-inducing factor homologous mitochondrion-associated inducer of death; Apoptosis-inducing factor-like mitochondrion-associated inducer of death |
Gene Name | Aifm2 |
Gene Synonyms/Alias | Amid |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 64 | VESGFAKKTFISYSA | ubiquitination | [1] | | 88 | KVIGIDLKNRMVLLQ | ubiquitination | [1] | | 182 | SRVPLADKELLPCVR | ubiquitination | [1] | | 366 | LLISTSWKTMRQSPP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death (By similarity). May contribute to genotoxin- induced growth arrest. |
Sequence Annotation | NP_BIND 18 22 FAD (Potential).
BINDING 54 54 FAD (Potential).
BINDING 82 82 FAD; via amide nitrogen and carbonyl
BINDING 285 285 FAD (Potential).
LIPID 2 2 N-myristoyl glycine (By similarity). |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; DNA-binding; FAD; Flavoprotein; Lipoprotein; Membrane; Mitochondrion; Mitochondrion outer membrane; Myristate; Oxidoreductase; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 373 AA |
Protein Sequence | MGSQVSVDTG AVHVVIVGGG FGGIAAASQL QALNVPFMLV DMKDSFHHNV AALRASVESG 60
FAKKTFISYS ATFKDNFRQG KVIGIDLKNR MVLLQGGEAL PFSHLILATG STGPFPGKFN 120
EVSCQQAAIQ AYEDMVKQIQ RSQFIVVVGG GSAGVEMAAE IKTEYPEKEV TLIHSRVPLA 180
DKELLPCVRQ EVKEILLRKG VQLLLSERVS NLEELPRNEY REYIKVETDK GTEVATNMVI 240
VCNGIKINSS AYRSAFESRL ASNGALKVNE FLQVEGYSNI YAIGDCADTK EPKMAYHAGL 300
HANVAVANIV NSMKQRPLKA YKPGALTFLL SMGRNDGVGQ ISGFYVGRLM VRLAKSRDLL 360
ISTSWKTMRQ SPP 373 |
Gene Ontology | GO:0005829; C:cytosol; ISS:UniProtKB. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005811; C:lipid particle; IEA:Compara. GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB. GO:0003677; F:DNA binding; ISS:UniProtKB. GO:0004174; F:electron-transferring-flavoprotein dehydrogenase activity; ISS:UniProtKB. GO:0050660; F:flavin adenine dinucleotide binding; ISS:UniProtKB. GO:0030261; P:chromosome condensation; ISS:UniProtKB. GO:0006917; P:induction of apoptosis; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |