UniProt Accession

 B7Z528_HUMAN; B7Z528 

Genbank Protein ID

 AC008817; AC034222; AC114946; AK298352; AK315902 

Genbank Nucleotide ID

 BAH12764.1; BAH14273.1 

Protein Name

 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial 

Protein Synonyms/Alias

 cDNA FLJ51924, highly similar to Succinyl-CoA:3-ketoacid-coenzyme A transferase1, mitochondrial (EC 2.8.3.5); cDNA, FLJ78801, highly similar to Succinyl-CoA:3-ketoacid-coenzyme A transferase1, mitochondrial (EC 2.8.3.5) 

Gene Name

 OXCT1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
24	MIPGKMVKGMGGAMD	acetylation	[1, 2]
24	MIPGKMVKGMGGAMD	ubiquitination	[3]
58	NAHKIMEKCTLPLTG	acetylation	[2, 4]

Reference

 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 123 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0008260; F:3-oxoacid CoA-transferase activity; IEA:Compara.
 GO:0060612; P:adipose tissue development; IEA:Compara.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0071229; P:cellular response to acid; IEA:Compara.
 GO:0071333; P:cellular response to glucose stimulus; IEA:Compara.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0046952; P:ketone body catabolic process; IEA:Compara.
 GO:0042182; P:ketone catabolic process; IEA:Compara.
 GO:0032024; P:positive regulation of insulin secretion; IEA:Compara.
 GO:0014823; P:response to activity; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0045471; P:response to ethanol; IEA:Compara.
 GO:0009725; P:response to hormone stimulus; IEA:Compara.
 GO:0007584; P:response to nutrient; IEA:Compara.
 GO:0042594; P:response to starvation; IEA:Compara. 

Interpro

 IPR004165; CoA_trans_fam_I. 

Pfam

 PF01144; CoA_trans 

SMART

  

PROSITE

  

PRINTS