UniProt Accession

 A6NDZ3_HUMAN; A6NDZ3; B4E3N3 

Genbank Protein ID

 AL079335; AL365505; AK304795 

Genbank Nucleotide ID

 BAG65545.1 

Protein Name

 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 

Protein Synonyms/Alias

 cDNA FLJ51783, highly similar to SAM domain and HD domain-containing protein 1 

Gene Name

 SAMHD1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
79	YKGRPENKSFLYEIV	ubiquitination	[1]
89	LYEIVSNKRNGIDVD	ubiquitination	[1, 2, 3]
97	RNGIDVDKWDYFARD	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 170 AA 

Protein Sequence

Gene Ontology

 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro. 

Interpro

 IPR006674; HD_domain. 

Pfam

  

SMART

  

PROSITE

  

PRINTS