CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043009
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 DUT 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
156PRSGLAAKHFIDVGAacetylation[1]
156PRSGLAAKHFIDVGAubiquitination[1, 2, 3, 4, 5]
185LFNFGKEKFEVKKGDubiquitination[5]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 221 AA 
Protein Sequence
MTPLCPRPAL CYHFLTSLLR SAMQNARGAR QRAEAAVLSG PGPPLGRAAQ HGIPRPLSSA 60
GRLSQGCRGA KTPAISPSKR ARPAEVGGMQ LRFARLSEHA TAPTRGSARA AGYDLYSAYD 120
YTIPPMEKAV VKTDIQIALP SGCYGRVAPR SGLAAKHFID VGAGVIDEDY RGNVGVVLFN 180
FGKEKFEVKK GDRIAQLICE RIFYPEIEEV QALDDTERGS G 221 
Gene Ontology
 GO:0004170; F:dUTP diphosphatase activity; IEA:InterPro.
 GO:0046080; P:dUTP metabolic process; IEA:InterPro. 
Interpro
 IPR008180; dUTP_pyroPase.
 IPR008181; dUTP_pyroPase_sf. 
Pfam
 PF00692; dUTPase 
SMART
  
PROSITE
  
PRINTS