UniProt Accession

 YLAT2_HUMAN; Q92536; Q68DS4; Q7L1N3 

Genbank Protein ID

 D87432; CR749291; CH471092; BC028216 

Genbank Nucleotide ID

 BAA13376.2; CAH18146.1; EAW83219.1; AAH28216.1 

Protein Name

 Y+L amino acid transporter 2 

Protein Synonyms/Alias

 Cationic amino acid transporter, y+ system; Solute carrier family 7 member 6; y(+)L-type amino acid transporter 2; Y+LAT2; y+LAT-2 

Gene Name

 SLC7A6 

Gene Synonyms/Alias

 KIAA0245 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
42	SSETMQLKKEISLLN	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells. 

Sequence Annotation

  

Keyword

 Amino-acid transport; Antiport; Cell membrane; Complete proteome; Disulfide bond; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 515 AA 

Protein Sequence

Gene Ontology

 GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0015171; F:amino acid transmembrane transporter activity; TAS:ProtInc.
 GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0006520; P:cellular amino acid metabolic process; TAS:ProtInc.
 GO:0050900; P:leukocyte migration; TAS:Reactome.
 GO:0006461; P:protein complex assembly; TAS:ProtInc. 

Interpro

 IPR002293; AA/rel_permease1. 

Pfam

  

SMART

  

PROSITE

 PS00218; AMINO_ACID_PERMEASE_1 

PRINTS