UniProt Accession

 GBB5_HUMAN; O14775; Q9HAU9; Q9UFT3 

Genbank Protein ID

 AF017656; AL117471; AF501885; AF300650; BC013997 

Genbank Nucleotide ID

 AAC63826.1; CAB55946.1; AAM15921.1; AAG18444.1; AAH13997.1 

Protein Name

 Guanine nucleotide-binding protein subunit beta-5 

Protein Synonyms/Alias

 Gbeta5; Transducin beta chain 5 

Gene Name

 GNB5 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
58	NETLASLKSEAESLK	ubiquitination	[1]
65	KSEAESLKGKLEEER	ubiquitination	[1, 2]
74	KLEEERAKLHDVELH	ubiquitination	[1]
115	VLCMDWCKDKRRIVS	ubiquitination	[1]
117	CMDWCKDKRRIVSSS	ubiquitination	[1]
180	VYPLTFDKNENMAAK	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. 

Sequence Annotation

 REPEAT 103 142 WD 1.
 REPEAT 145 184 WD 2.
 REPEAT 193 234 WD 3.
 REPEAT 236 278 WD 4.
 REPEAT 279 318 WD 5.
 REPEAT 320 362 WD 6.
 REPEAT 365 394 WD 7.  

Keyword

 Alternative splicing; Complete proteome; Polymorphism; Reference proteome; Repeat; Transducer; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 395 AA 

Protein Sequence

Gene Ontology

 GO:0005834; C:heterotrimeric G-protein complex; NAS:UniProtKB.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0003924; F:GTPase activity; NAS:UniProtKB.
 GO:0004871; F:signal transducer activity; NAS:UniProtKB.
 GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:Compara. 

Interpro

 IPR020472; G-protein_beta_WD-40_rep.
 IPR001632; Gprotein_B.
 IPR016346; Guanine_nucleotide-bd_bsu.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS

 PR00319; GPROTEINB.
 PR00320; GPROTEINBRPT.