CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033264
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 U2 snRNP-associated SURP motif-containing protein 
Protein Synonyms/Alias
  
Gene Name
 U2SURP 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
43AHVYYRWKLYSILQGubiquitination[1]
55LQGDSPTKWRTEDFRubiquitination[1, 2, 3, 4]
97AFVEEPSKKGALKEEubiquitination[2]
108LKEEQRDKLEEILRGubiquitination[1, 2, 3, 4]
175VLYNSSAKVANASYYubiquitination[2, 3]
189YRKFFETKLCQIFSDubiquitination[2, 3]
214HLQSENFKQRVMTCFubiquitination[2, 3, 4, 5]
327IFKVAPSKWEAVDESacetylation[4, 6, 7]
327IFKVAPSKWEAVDESubiquitination[5]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [6] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [7] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 488 AA 
Protein Sequence
MIEFVVREGP MFEAMIMNRE INNPMFRFLF ENQTPAHVYY RWKLYSILQG DSPTKWRTED 60
FRMFKNGSFW RPPPLNPYLH GMSEEQETEA FVEEPSKKGA LKEEQRDKLE EILRGLTPRK 120
NDIGDAMVFC LNNAEAAEEI VDCITESLSI LKTPLPKKIA RLYLVSDVLY NSSAKVANAS 180
YYRKFFETKL CQIFSDLNAT YRTIQGHLQS ENFKQRVMTC FRAWEDWAIY PEPFLIKLQN 240
IFLGLVNIIE EKETEDVPDD LDGAPIEEEL DGAPLEDVDG IPIDATPIDD LDGVPIKSLD 300
DDLDGVPLDA TEDSKKNEPI FKVAPSKWEA VDESELEAQA VTTSKWELFD QHEESEEEEN 360
QNQEEESEDE EDTQSSKSEE HHLYSNPIKE EMTESKFSKY SEMSEEKRAK LREIELKVMK 420
FQDELESGKR PKKPGQSFQE QVEHYRDKLL QREKEKELER ERERDKKDKE KLESRSKDKK 480
EKDECTPT 488 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0006396; P:RNA processing; IEA:InterPro. 
Interpro
 IPR006569; CID_dom.
 IPR008942; ENTH_VHS.
 IPR013170; mRNA_splic_Cwf21.
 IPR000061; Surp. 
Pfam
 PF08312; cwf21
 PF01805; Surp 
SMART
 SM00582; RPR
 SM00648; SWAP 
PROSITE
 PS51391; CID
 PS50128; SURP 
PRINTS