CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039433
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Sos2 
Protein Synonyms/Alias
  
Gene Name
 Sos2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
912ELSQDHFKKYLVKLKubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Guanine-nucleotide releasing factor; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1333 AA 
Protein Sequence
MQQAPQPYEF FSEENSPKWR GLLVPALRKV QEQVHPTLSA NEESLYYIEE LIFQLLNKLC 60
LAQPRTVQDV EERVQKTFPH PIDKWAIADA QSAIEKRKRR NPLLLPVDKI HPSLKEVLGY 120
KVDYHVSLYI VAVLEYISAD ILKLAGNYVF NIRHYEISQQ DIKVSMCADK VLMDMFDQDD 180
DIGLVSLCEE EPCSSGELNY YDLVRTEIAE ERQYLRELNM IIKVFREAFL SDKKLFKSSE 240
IEKIFSNISD IHELTVKLLG LIEDTVEMTD ESSPHPLAGS CFEDLAEEQA FDPYETLSQD 300
ILAPEFNDHF SKLMARPAVA LHFQSIADGF KEAVRYVLPR LMLVPVYHCW HYFELLKQLK 360
ACSEEQEDRE CLNQAITALM NLQGSMDRIY KQHSPRRRPG DPVCLFYNRQ LRSKHLAIKK 420
MNEIQKNIDG WEGKDIGQCC NEFIMEGPLT RIGAKHERHI FLFDGLMISC KPNHCQTRLP 480
GYSSAEYRLK EKFVMRKIQI CDKEDACEYK HAFELVSKDE NSVIFAAKSA EEKNNWMAAL 540
ISLHYRSTLD RMLDSVLLKE ENEQPLRLPR PDVYRFVVTD SEENIVFEDN LQSRSGIPII 600
KGGTVVKLIE RLTYHMYADP NFVRTFLTTY RSFCKPQELL SLLIERFEIP DPEPTEADKL 660
ALEKGEQPIS ADLKRFRKEY VQPVQLRVLN VFRHWVEHHF YDFERDLELL ERLEAFISSV 720
RGKAMKKWVE SIAKIIKRKK QAQANGVSHN ITFESPPPPV EWHISRAGQS ETFDLMTLHP 780
IEIARQLTLL ESDLYRRVQP SELVGSVWTK EDKEINSPNL LKMIRHTTNL TLWFEKCIVE 840
AENFEERVAV LSRIVEILQV FQDLNNFNGV LEIVSAVNSV SVYRLDHTFE ALQERKRRVL 900
DDAVELSQDH FKKYLVKLKS INPPCVPFFG IYLTNILKTE EGNSDFLKRK GKDLINFSKR 960
RKVAEITGEI QQYQNQPYCL RTEPEMRRFF ENLNPMGLLS EKEFTDYLFN KSHEIEPRNC 1020
KQPPRFPRKS TFSLKSPGIR PNASRHGSTS GTFRGHPTPL EREPYKISFS RIAETELEST 1080
VSAPTSPNTP STPPVSASSD HSVFLDVDLN SSCGSNTIFA PVLLPHSKSF FSSCGSLHKL 1140
SEEPLVPPPL PPRKKFDHDA PNSKGAMKSD DDPPAIPPRQ PPPPKVKPRA PVLTGTFEGP 1200
VPSPPPPPPR DPLPDTPPPV PLRPPEHFIN CPFNLQPPPL GHPHRDPDWL RDVSTCPNSP 1260
STPPPTPSPR IPRRCHLPSP SHNNLAHPPA PPVPPRQNSS PHLPKLPPKT YKRELSHPPL 1320
YRLPLFENAE TPQ 1333 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0043234; C:protein complex; IC:RGD.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0051057; P:positive regulation of small GTPase mediated signal transduction; IMP:RGD.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:Compara. 
Interpro
 IPR000219; DH-domain.
 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR000651; Ras-like_Gua-exchang_fac_N.
 IPR019804; Ras_G-nucl-exch_fac_CS.
 IPR008937; Ras_GEF.
 IPR023578; Ras_GEF_dom.
 IPR001895; RasGRF_CDC25.
 IPR015759; Sos. 
Pfam
 PF00125; Histone
 PF00169; PH
 PF00617; RasGEF
 PF00618; RasGEF_N
 PF00621; RhoGEF 
SMART
 SM00233; PH
 SM00147; RasGEF
 SM00229; RasGEFN
 SM00325; RhoGEF 
PROSITE
 PS50010; DH_2
 PS50003; PH_DOMAIN
 PS00720; RASGEF
 PS50009; RASGEF_CAT
 PS50212; RASGEF_NTER 
PRINTS