UniProt Accession

 IGHG2_HUMAN; P01859; A6NE66 

Genbank Protein ID

 AL928742; J00230 

Genbank Nucleotide ID

 AAB59393.1 

Protein Name

 Ig gamma-2 chain C region 

Protein Synonyms/Alias

  

Gene Name

 IGHG2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
30	AALGCLVKDYFPEPV	glycation	[1]
101	VDKTVERKCCVECPP	glycation	[2]
127	FLFPPKPKDTLMISR	glycation	[1]
167	GVEVHNAKTKPREEQ	glycation	[2]
196	HQDWLNGKEYKCKVS	glycation	[1, 2]
199	WLNGKEYKCKVSNKG	glycation	[2]
205	YKCKVSNKGLPAPIE	glycation	[1, 2]
271	GQPENNYKTTPPMLD	glycation	[1]

Reference

 [1] Characterization of nonenzymatic glycation on a monoclonal antibody.
 Brady LJ, Martinez T, Balland A.
 Anal Chem. 2007 Dec 15;79(24):9403-13. [PMID: 17985928]
 [2] The LC/MS analysis of glycation of IgG molecules in sucrose containing formulations.
 Gadgil HS, Bondarenko PV, Pipes G, Rehder D, McAuley A, Perico N, Dillon T, Ricci M, Treuheit M.
 J Pharm Sci. 2007 Oct;96(10):2607-21. [PMID: 17621682] 

Functional Description

  

Sequence Annotation

 REGION 1 98 CH1.
 REGION 99 110 Hinge.
 REGION 111 219 CH2.
 REGION 220 326 CH3.
 CARBOHYD 176 176 N-linked (GlcNAc...).
 DISULFID 14 14 Interchain (with a light chain).
 DISULFID 27 83
 DISULFID 102 102 Interchain (with a heavy chain).
 DISULFID 103 103 Interchain (with a heavy chain).
 DISULFID 106 106 Interchain (with a heavy chain).
 DISULFID 109 109 Interchain (with a heavy chain).
 DISULFID 140 200
 DISULFID 246 304  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin C region; Immunoglobulin domain; Reference proteome; Secreted. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 326 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; TAS:Reactome.
 GO:0016020; C:membrane; NAS:UniProtKB.
 GO:0003823; F:antigen binding; IEA:UniProtKB-KW.
 GO:0006958; P:complement activation, classical pathway; TAS:Reactome.
 GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome.
 GO:0045087; P:innate immune response; TAS:Reactome. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003006; Ig/MHC_CS.
 IPR003597; Ig_C1-set. 

Pfam

 PF07654; C1-set 

SMART

 SM00407; IGc1 

PROSITE

 PS50835; IG_LIKE
 PS00290; IG_MHC 

PRINTS