CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010380
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 Transcription elongation factor GreA 
Protein Synonyms/Alias
 Transcript cleavage factor GreA 
Gene Name
 greA 
Gene Synonyms/Alias
 MPN_401; MP437 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
54NADYDAAKAQQGEIEacetylation[1]
83LINESQTKKANKVTLacetylation[1]
156PYRVKIVKIINW***acetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819
Functional Description
 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity). 
Sequence Annotation
  
Keyword
 Coiled coil; Complete proteome; DNA-binding; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 160 AA 
Protein Sequence
MELNKNYLTE EGLKQLEAEL EHLIQVKRPA IIKLLQEARD QGDLSENADY DAAKAQQGEI 60
ETRIAEIQDI LANVKLINES QTKKANKVTL GSTVEIYDYS SKTHEKYTIV GALEANPEEH 120
RISNESPLAH AIYGRLVDDE CDVVGIEVPY RVKIVKIINW 160 
Gene Ontology
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0032784; P:regulation of DNA-dependent transcription, elongation; IEA:InterPro.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR018151; TF_GreA/GreB_CS.
 IPR006359; Tscrpt_elong_fac_GreA.
 IPR023459; Tscrpt_elong_fac_GreA/B.
 IPR001437; Tscrpt_elong_fac_GreA/B_C.
 IPR022691; Tscrpt_elong_fac_GreA/B_N. 
Pfam
 PF01272; GreA_GreB
 PF03449; GreA_GreB_N 
SMART
  
PROSITE
 PS00829; GREAB_1
 PS00830; GREAB_2 
PRINTS