CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005549
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Activin receptor type-2A 
Protein Synonyms/Alias
 Activin receptor type IIA; ACTR-IIA; ACTRIIA 
Gene Name
 ACVR2A 
Gene Synonyms/Alias
 ACVR2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
226KIFPIQDKQSWQNEYubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. 
Sequence Annotation
 DOMAIN 192 485 Protein kinase.
 NP_BIND 198 206 ATP (By similarity).
 ACT_SITE 322 322 Proton acceptor (By similarity).
 BINDING 219 219 ATP (By similarity).
 CARBOHYD 43 43 N-linked (GlcNAc...) (Potential).
 CARBOHYD 66 66 N-linked (GlcNAc...) (Potential).
 DISULFID 30 60 By similarity.
 DISULFID 50 78 By similarity.
 DISULFID 85 104 By similarity.
 DISULFID 91 103 By similarity.
 DISULFID 105 110 By similarity.  
Keyword
 3D-structure; ATP-binding; Complete proteome; Disulfide bond; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Polymorphism; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 513 AA 
Protein Sequence
MGAAAKLAFA VFLISCSSGA ILGRSETQEC LFFNANWEKD RTNQTGVEPC YGDKDKRRHC 60
FATWKNISGS IEIVKQGCWL DDINCYDRTD CVEKKDSPEV YFCCCEGNMC NEKFSYFPEM 120
EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI AGIVICAFWV YRHHKMAYPP VLVPTQDPGP 180
PPPSPLLGLK PLQLLEVKAR GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG 240
MKHENILQFI GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL 300
AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV 360
GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFEEEIG 420
QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG MAMLCETIEE CWDHDAEARL SAGCVGERIT 480
QMQRLTNIIT TEDIVTVVTM VTNVDFPPKE SSL 513 
Gene Ontology
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:HGNC.
 GO:0034673; C:inhibin-betaglycan-ActRII complex; IDA:BHF-UCL.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0017002; F:activin-activated receptor activity; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0015026; F:coreceptor activity; IDA:BHF-UCL.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004702; F:receptor signaling protein serine/threonine kinase activity; IEA:InterPro.
 GO:0005024; F:transforming growth factor beta-activated receptor activity; IEA:InterPro.
 GO:0004675; F:transmembrane receptor protein serine/threonine kinase activity; TAS:ProtInc.
 GO:0009952; P:anterior/posterior pattern specification; IEA:Compara.
 GO:0030509; P:BMP signaling pathway; IDA:BHF-UCL.
 GO:0007368; P:determination of left/right symmetry; IEA:Compara.
 GO:0048706; P:embryonic skeletal system development; IEA:Compara.
 GO:0001702; P:gastrulation with mouth forming second; IEA:Compara.
 GO:0007498; P:mesoderm development; IEA:Compara.
 GO:0043084; P:penile erection; IEA:Compara.
 GO:0032927; P:positive regulation of activin receptor signaling pathway; IDA:HGNC.
 GO:0030501; P:positive regulation of bone mineralization; IMP:BHF-UCL.
 GO:0045648; P:positive regulation of erythrocyte differentiation; IDA:HGNC.
 GO:0045669; P:positive regulation of osteoblast differentiation; IMP:BHF-UCL.
 GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IMP:BHF-UCL.
 GO:0030510; P:regulation of BMP signaling pathway; IEA:Compara.
 GO:0050999; P:regulation of nitric-oxide synthase activity; IEA:Compara.
 GO:0060011; P:Sertoli cell proliferation; IEA:Compara.
 GO:0023014; P:signal transduction by phosphorylation; IEA:GOC.
 GO:0042713; P:sperm ejaculation; IEA:Compara.
 GO:0007283; P:spermatogenesis; IEA:Compara. 
Interpro
 IPR000333; Activin_II/TGFBeta-II_recpt.
 IPR015768; Activin_II_recpt.
 IPR000472; Activin_rcpt.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF01064; Activin_recp
 PF00069; Pkinase 
SMART
  
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS
 PR00653; ACTIVIN2R.