UniProt Accession

 ARK73_RAT; P38918; Q5EBB7; Q68FZ3; Q9QX16 

Genbank Protein ID

 X74673; AF045464; AY230497; AY230491; AY230492; AY230493; AY230494; AY230495; AY230496; BC078872; BC089811 

Genbank Nucleotide ID

 CAA52740.1; AAD02413.1; AAO48423.1; AAO48423.1; AAO48423.1; AAO48423.1; AAO48423.1; AAO48423.1; AAO48423.1; AAH78872.2; AAH89811.1 

Protein Name

 Aflatoxin B1 aldehyde reductase member 3 

Protein Synonyms/Alias

 AFB1-AR; Aflatoxin B1 aldehyde reductase member 1; rAFAR1 

Gene Name

 Akr7a3 

Gene Synonyms/Alias

 Afar; Akr7a1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
80	KAAPMFGKTLKPADV	acetylation	[1]
83	PMFGKTLKPADVRFQ	acetylation	[1]
96	FQLETSLKRLQCPRV	acetylation	[1]
246	NGIALVEKALKTTYG	acetylation	[1]
249	ALVEKALKTTYGPTA	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. Probably involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. 

Sequence Annotation

 NP_BIND 139 140 NADP.
 NP_BIND 194 204 NADP.
 NP_BIND 286 294 NADP.
 ACT_SITE 45 45 Proton donor.
 BINDING 40 40 NADP.
 BINDING 109 109 Substrate.
 BINDING 165 165 NADP.
 BINDING 218 218 NADP.
 BINDING 228 228 Substrate.
 BINDING 231 231 Substrate.
 BINDING 327 327 NADP.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Detoxification; Direct protein sequencing; NAD; NADP; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 327 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; IDA:RGD.
 GO:0046223; P:aflatoxin catabolic process; IMP:RGD.
 GO:0009636; P:response to toxic substance; IEA:UniProtKB-KW. 

Interpro

 IPR001395; Aldo/ket_red.
 IPR020471; Aldo/keto_reductase_subgr.
 IPR023210; NADP_OxRdtase_dom. 

Pfam

 PF00248; Aldo_ket_red 

SMART

  

PROSITE

  

PRINTS

 PR00069; ALDKETRDTASE.