CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038073
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Adenosylhomocysteinase 
Protein Synonyms/Alias
  
Gene Name
 Ahcyl2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
359KKYPNMFKKIKGIVEacetylation[1]
380HRLYQLSKAGKLCVPubiquitination[2]
600DVYLLPKKMDEYVASubiquitination[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; NAD; One-carbon metabolism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 643 AA 
Protein Sequence
MGEGRGREAG GGAEWELVRE SESAVAVEAV MSVQVVSAAA AAKVPEVELK DLSPSEAEPQ 60
LGLSAAAVGA MVPPAGGGDP EAPAPAPAAE RPPAPGPGSG PTAALSPAAG KVPQASAMKR 120
SDPHHQHQRH RDGGEALVSP DGTVTEAPRT VKKQIQFADQ KQEFNKRPTK IGRRSLSRSI 180
SQSSTDSYSS AASYTDSSDD ETSPRDKQQK NSKGSSDFCV KNIKQAEFGR REIEIAEQEM 240
PALMALRKRA QGEKPLAGAK IVGCTHITAQ TAVLMETLGA LGAQCRWAAC NIYSTLNEVA 300
AALAESGFPV FAWKGESEDD FWWCIDRCVN VEGWQPNMIL DDGGDLTHWI YKKYPNMFKK 360
IKGIVEESVT GVHRLYQLSK AGKLCVPAMN VNDSVTKQKF DNLYCCRESI LDGLKRTTDM 420
MFGGKQVVVC GYGEVGKGCC AALKAMGSIV YVTEIDPICA LQACMDGFRL VKLNEVIRQV 480
DIVITCTGNK NVVTREHLDR MKNSCIVCNM GHSNTEIDVA SLRTPELTWE RVRSQVDHVI 540
WPDGKRIVLL AEGRLLNLSC STVPTFVLSI TATTQALALI ELYNAPEGRY KQDVYLLPKK 600
MDEYVASLHL PTFDAHLTEL TDEQAKYLGL NKNGPFKPNY YRY 643 
Gene Ontology
 GO:0004013; F:adenosylhomocysteinase activity; IEA:EC.
 GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. 
Interpro
 IPR000043; Adenosylhomocysteinase.
 IPR015878; Ado_hCys_hydrolase_NAD-bd.
 IPR016040; NAD(P)-bd_dom.
 IPR020082; S-Ado-L-homoCys_hydrolase_CS. 
Pfam
 PF05221; AdoHcyase
 PF00670; AdoHcyase_NAD 
SMART
 SM00996; AdoHcyase
 SM00997; AdoHcyase_NAD 
PROSITE
 PS00738; ADOHCYASE_1
 PS00739; ADOHCYASE_2 
PRINTS