UniProt Accession

 RSSA_MOUSE; P14206; Q58E74; Q8BHL0; Q8BNL2; Q91V31; Q9CY13 

Genbank Protein ID

 J02870; X06406; AF140348; DQ360291; DQ360292; AK010423; AK010985; AK011041; AK011043; AK075778; AK075790; AK082935; AK088954; AK134224; AK135488; AK160551; AK160625; AK165219; AK166697; AK166874; AK167132; BC003829; BC037195; BC055886; BC081461; BC084677; BC092041; BC094902; BC099601; BC110285 

Genbank Nucleotide ID

 AAA39413.1; CAA29696.1; AAD26866.1; ABC95972.1; ABC95977.1; BAB26926.1; BAB27306.1; BAB27353.1; BAB27355.1; BAC35952.1; BAC35960.1; BAC38701.1; BAC40671.1; BAE22057.1; BAE22550.1; BAE35867.1; BAE35924.1; BAE38083.1; BAE38953.1; BAE39085.1; BAE39278.1; AAH03829.1; AAH37195.1; AAH55886.1; AAH81461.1; AAH84677.1; AAH92041.1; AAH94902.1; AAH99601.1; AAI10286.1 

Protein Name

 40S ribosomal protein SA 

Protein Synonyms/Alias

 37 kDa laminin receptor precursor; 37LRP; 37 kDa oncofetal antigen; 37/67 kDa laminin receptor; LRP/LR; 67 kDa laminin receptor; 67LR; Laminin receptor 1; LamR; Laminin-binding protein precursor p40; LBP/p40; OFA/iLRP 

Gene Name

 Rpsa 

Gene Synonyms/Alias

 Lamr1; P40-8 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
11	ALDVLQMKEEDVLKF	acetylation	[1]
11	ALDVLQMKEEDVLKF	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA (By similarity). Enables malignant tumor cells to penetrate laminin tissue and vessel barriers. Activates precursor thymic anti- OFA/iLRP specific cytotoxic T-cell. May induce CD8 T-suppressor cells secreting IL-10. 

Sequence Annotation

 REPEAT 230 232 [DE]-W-[ST] 1.
 REPEAT 247 249 [DE]-W-[ST] 2.
 REPEAT 266 268 [DE]-W-[ST] 3.
 REPEAT 275 277 [DE]-W-[ST] 4.
 REPEAT 293 295 [DE]-W-[ST] 5.
 REGION 54 113 Interaction with PPP1R16B (By
 REGION 161 180 Laminin-binding (By similarity).
 REGION 205 229 Laminin-binding (By similarity).
 REGION 242 295 Laminin-binding (By similarity).
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 43 43 Phosphoserine.
 MOD_RES 52 52 N6-acetyllysine (By similarity).
 MOD_RES 139 139 Phosphotyrosine (By similarity).  

Keyword

 Acetylation; Cell membrane; Complete proteome; Cytoplasm; Direct protein sequencing; Membrane; Nucleus; Phosphoprotein; Receptor; Reference proteome; Repeat; Ribonucleoprotein; Ribosomal protein. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 295 AA 

Protein Sequence

Gene Ontology

 GO:0030686; C:90S preribosome; IBA:RefGenome.
 GO:0022627; C:cytosolic small ribosomal subunit; IBA:RefGenome.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0005886; C:plasma membrane; ISS:UniProtKB.
 GO:0043236; F:laminin binding; IDA:MGI.
 GO:0005055; F:laminin receptor activity; IEA:HAMAP.
 GO:0003735; F:structural constituent of ribosome; IBA:RefGenome.
 GO:0007155; P:cell adhesion; IEA:HAMAP.
 GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:RefGenome.
 GO:0000461; P:endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:RefGenome.
 GO:0000028; P:ribosomal small subunit assembly; IBA:RefGenome.
 GO:0006407; P:rRNA export from nucleus; IBA:RefGenome.
 GO:0006412; P:translation; IBA:RefGenome. 

Interpro

 IPR027504; 40S_ribosomal_SA.
 IPR001865; Ribosomal_S2.
 IPR018130; Ribosomal_S2_CS.
 IPR027498; Ribosomal_S2_euk.
 IPR005707; Ribosomal_S2_euk/arc.
 IPR023591; Ribosomal_S2_flav_dom. 

Pfam

 PF00318; Ribosomal_S2 

SMART

  

PROSITE

 PS00962; RIBOSOMAL_S2_1
 PS00963; RIBOSOMAL_S2_2 

PRINTS

 PR00395; RIBOSOMALS2.