CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000655
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Signal-induced proliferation-associated 1-like protein 1 
Protein Synonyms/Alias
 SIPA1-like protein 1; High-risk human papilloma viruses E6 oncoproteins targeted protein 1; E6-targeted protein 1 
Gene Name
 SIPA1L1 
Gene Synonyms/Alias
 E6TP1; KIAA0440 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
797NAENAAHKSEKFRAMubiquitination[1]
800NAAHKSEKFRAMATRubiquitination[1]
1059EGVSYEFKFPFRNNNubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F- actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). 
Sequence Annotation
 DOMAIN 613 830 Rap-GAP.
 DOMAIN 967 1045 PDZ.
 MOD_RES 162 162 Phosphoserine.
 MOD_RES 288 288 Phosphoserine.
 MOD_RES 1181 1181 Phosphoserine.
 MOD_RES 1255 1255 Phosphoserine.
 MOD_RES 1270 1270 Phosphoserine.
 MOD_RES 1326 1326 Phosphoserine; by PLK2 (By similarity).
 MOD_RES 1330 1330 Phosphothreonine; by PLK2 (By
 MOD_RES 1349 1349 Phosphoserine; by CDK5 (By similarity).
 MOD_RES 1431 1431 Phosphoserine.
 MOD_RES 1433 1433 Phosphoserine.
 MOD_RES 1528 1528 Phosphoserine (By similarity).
 MOD_RES 1549 1549 Phosphoserine.
 MOD_RES 1551 1551 Phosphothreonine.
 MOD_RES 1554 1554 Phosphoserine.
 MOD_RES 1565 1565 Phosphoserine.
 MOD_RES 1568 1568 Phosphoserine.
 MOD_RES 1585 1585 Phosphoserine.
 MOD_RES 1734 1734 Phosphoserine.  
Keyword
 Alternative splicing; Cell junction; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; GTPase activation; Membrane; Phosphoprotein; Polymorphism; Postsynaptic cell membrane; Reference proteome; Synapse; Synaptosome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1804 AA 
Protein Sequence
MTSLKRSQTE RPLATDRASV VGTDGTPKVH TDDFYMRRFR SQNGSLGSSV MAPVGPPRSE 60
GSHHITSTPG VPKMGVRARI ADWPPRKENI KESSRSSQEI ETSSCLDSLS SKSSPVSQGS 120
SVSLNSNDSA MLKSIQNTLK NKTRPSENMD SRFLMPEAYP SSPRKALRRI RQRSNSDITI 180
SELDVDSFDE CISPTYKTGP SLHREYGSTS SIDKQGTSGE SFFDLLKGYK DDKSDRGPTP 240
TKLSDFLITG GGKGSGFSLD VIDGPISQRE NLRLFKEREK PLKRRSKSET GDSSIFRKLR 300
NAKGEELGKS SDLEDNRSED SVRPWTCPKC FAHYDVQSIL FDLNEAIMNR HNVIKRRNTT 360
TGASAAAVAS LVSGPLSHSA SFSSPMGSTE DLNSKGSLSM DQGDDKSNEL VMSCPYFRNE 420
IGGEGERKIS LSKSNSGSFS GCESASFEST LSSHCTNAGV AVLEVPKENL VLHLDRVKRY 480
IVEHVDLGAY YYRKFFYQKE HWNYFGADEN LGPVAVSIRR EKPDEMKENG SPYNYRIIFR 540
TSELMTLRGS VLEDAIPSTA KHSTARGLPL KEVLEHVVPE LNVQCLRLAF NTPKVTEQLM 600
KLDEQGLNYQ QKVGIMYCKA GQSTEEEMYN NESAGPAFEE FLQLLGERVR LKGFEKYRAQ 660
LDTKTDSTGT HSLYTTYKDY EIMFHVSTML PYTPNNKQQL LRKRHIGNDI VTIVFQEPGA 720
QPFSPKNIRS HFQHVFVIVR VHNPCSDSVC YSVAVTRSRD VPSFGPPIPK GVTFPKSNVF 780
RDFLLAKVIN AENAAHKSEK FRAMATRTRQ EYLKDLAEKN VTNTPIDPSG KFPFISLASK 840
KKEKSKPYPG AELSSMGAIV WAVRAEDYNK AMELDCLLGI SNEFIVLIEQ ETKSVVFNCS 900
CRDVIGWTST DTSLKIFYER GECVSVGSFI NIEEIKEIVK RLQFVSKGCE SVEMTLRRNG 960
LGQLGFHVNY EGIVADVEPY GYAWQAGLRQ GSRLVEICKV AVATLSHEQM IDLLRTSVTV 1020
KVVIIPPHDD CTPRRSCSET YRMPVMEYKM NEGVSYEFKF PFRNNNKWQR NASKGPHSPQ 1080
VPSQVQSPMT SRLNAGKGDG KMPPPERAAN IPRSISSDGR PLERRLSPGS DIYVTVSSMA 1140
LARSQCRNSP SNLSSSSDTG SVGGTYRQKS MPEGFGVSRR SPASIDRQNT QSDIGGSGKS 1200
TPSWQRSEDS IADQMAYSYR GPQDFNSFVL EQHEYTEPTC HLPAVSKVLP AFRESPSGRL 1260
MRQDPVVHLS PNKQGHSDSH YSSHSSSNTL SSNASSAHSD EKWYDGDRTE SELNSYNYLQ 1320
GTSADSGIDT TSYGPSHGST ASLGAATSSP RSGPGKEKVA PLWHSSSEVI SMADRTLETE 1380
SHGLDRKTES SLSLDIHSKS QAGSTPLTRE NSTFSINDAA SHTSTMSSRH SASPVVFTSA 1440
RSSPKEELHP AAPSQLAPSF SSSSSSSSGP RSFYPRQGAT SKYLIGWKKP EGTINSVGFM 1500
DTRKRHQSDG NEIAHTRLRA STRDLRASPK PTSKSTIEED LKKLIDLESP TPESQKSFKF 1560
HALSSPQSPF PSTPTSRRAL HRTLSDESIY NSQREHFFTS RASLLDQALP NDVLFSSTYP 1620
SLPKSLPLRR PSYTLGMKSL HGEFSASDSS LTDIQETRRQ PMPDPGLMPL PDTAADLDWS 1680
NLVDAAKAYE VQRASFFAAS DENHRPLSAA SNSDQLEDQA LAQMKPYSSS KDSSPTLASK 1740
VDQLEGMLKM LREDLKKEKE DKAHLQAEVQ HLREDNLRLQ EESQNASDKL KKFTEWVFNT 1800
IDMS 1804 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0014069; C:postsynaptic density; ISS:UniProtKB.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
 GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
 GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB.
 GO:0032861; P:activation of Rap GTPase activity; ISS:UniProtKB.
 GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.
 GO:0050770; P:regulation of axonogenesis; ISS:UniProtKB.
 GO:0061001; P:regulation of dendritic spine morphogenesis; ISS:UniProtKB.
 GO:0048167; P:regulation of synaptic plasticity; ISS:UniProtKB. 
Interpro
 IPR021818; DUF3401.
 IPR001478; PDZ.
 IPR000331; Rap_GAP_dom. 
Pfam
 PF11881; DUF3401
 PF02145; Rap_GAP 
SMART
 SM00228; PDZ 
PROSITE
 PS50106; PDZ
 PS50085; RAPGAP 
PRINTS