CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016688
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Peroxisomal N(1)-acetyl-spermine/spermidine oxidase 
Protein Synonyms/Alias
 Polyamine oxidase 
Gene Name
 Paox 
Gene Synonyms/Alias
 Pao 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
231RILASLPKDTVAFDKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Flavoenzyme which catalyzes the oxidation of N(1)- acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)- acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. 
Sequence Annotation
 MOTIF 502 504 Microbody targeting signal (Potential).  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; FAD; Flavoprotein; Oxidoreductase; Peroxisome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 504 AA 
Protein Sequence
MAFPGPRVLV VGSGIAGLGA AQKLCSHRAA PHLRVLEATA SAGGRIRSER CFGGVVELGA 60
HWIHGPSQDN PVFQLAAEFG LLGEKELSEE NQLVDTGGHV ALPSMIWSSS GTSVSLELMT 120
EMARLFYGLI ERTREFLNES ETPMASVGEF LKKEISQQVA SWTEDDEDTR KRKLAILNTF 180
FNIECCVSGT HSMDLVALAP FGEYTVLPGL DCILAGGYQG LTDRILASLP KDTVAFDKPV 240
KTIHWNGSFQ EAAFPGETFP VLVECEDGAR LPAHHVIVTV PLGFLKEHQD TFFEPPLPAK 300
KAEAIKKLGF GTNNKIFLEF EEPFWEPDCQ FIQVVWEDTS PLQDTALSLQ DTWFKKLIGF 360
LVQPSFESSH VLCGFIAGLE SEFMETLSDE EVLLSLTQVL RRVTGNPQLP AAKSVRRSQW 420
HSAPYTRGSY SYVAVGSTGD DLDLMAQPLP EDGTGTQLQV LFAGEATHRT FYSTTHGALL 480
SGWREADRLV SLWDSQVEQS RPRL 504 
Gene Ontology
 GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
 GO:0052899; F:N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity; IEA:EC.
 GO:0052904; F:N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity; IEA:EC.
 GO:0052903; F:N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity; IEA:EC.
 GO:0046592; F:polyamine oxidase activity; IDA:MGI.
 GO:0052902; F:spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity; IEA:EC.
 GO:0052901; F:spermine:oxygen oxidoreductase (spermidine-forming) activity; IEA:EC.
 GO:0006598; P:polyamine catabolic process; IDA:MGI.
 GO:1901307; P:positive regulation of spermidine biosynthetic process; IEA:Compara.
 GO:0009446; P:putrescine biosynthetic process; IEA:Compara.
 GO:0009447; P:putrescine catabolic process; IEA:Compara.
 GO:0046203; P:spermidine catabolic process; IEA:Compara.
 GO:0046208; P:spermine catabolic process; IEA:Compara. 
Interpro
 IPR002937; Amino_oxidase.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF01593; Amino_oxidase 
SMART
  
PROSITE
  
PRINTS