UniProt Accession

 HNF6_HUMAN; Q9UBC0; B2RTV4; Q99744; Q9UMR6 

Genbank Protein ID

 AF035581; AF035580; U96173; CH471082; BC140830; Y17739; U77975 

Genbank Nucleotide ID

 AAD02033.1; AAD02033.1; AAD00826.1; EAW77461.1; AAI40831.1; CAB50769.1; AAB61705.1 

Protein Name

 Hepatocyte nuclear factor 6 

Protein Synonyms/Alias

 HNF-6; One cut domain family member 1; One cut homeobox 1 

Gene Name

 ONECUT1 

Gene Synonyms/Alias

 HNF6; HNF6A 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
339	RNPKPWSKLKSGRET	acetylation	[1]

Reference

 [1] Stability of the hepatocyte nuclear factor 6 transcription factor requires acetylation by the CREB-binding protein coactivator.
 Rausa FM 3rd, Hughes DE, Costa RH.
 J Biol Chem. 2004 Oct 8;279(41):43070-6. [PMID: 15304484] 

Functional Description

 Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription. 

Sequence Annotation

 DNA_BIND 283 369 CUT.
 DNA_BIND 385 444 Homeobox.  

Keyword

 Activator; Complete proteome; DNA-binding; Homeobox; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 465 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; ISS:BHF-UCL.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0030183; P:B cell differentiation; IEA:Compara.
 GO:0045165; P:cell fate commitment; IEA:Compara.
 GO:0042384; P:cilium assembly; IEA:Compara.
 GO:0031018; P:endocrine pancreas development; TAS:Reactome.
 GO:0007492; P:endoderm development; IEA:Compara.
 GO:0002064; P:epithelial cell development; IEA:Compara.
 GO:0006006; P:glucose metabolic process; IEA:Compara.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Compara.
 GO:0030335; P:positive regulation of cell migration; IEA:Compara.
 GO:0001952; P:regulation of cell-matrix adhesion; IEA:Compara.
 GO:0048536; P:spleen development; IEA:Compara. 

Interpro

 IPR003350; Hmoeo_CUT.
 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like.
 IPR010982; Lambda_DNA-bd_dom. 

Pfam

 PF02376; CUT
 PF00046; Homeobox 

SMART

 SM00389; HOX 

PROSITE

 PS51042; CUT
 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2 

PRINTS