UniProt Accession

 ZYX_MOUSE; Q62523; P70461; Q3UGQ3 

Genbank Protein ID

 Y07711; X99063; AK147812; CH466533 

Genbank Nucleotide ID

 CAA68984.1; CAA67510.1; BAE28154.1; EDL13482.1 

Protein Name

 Zyxin 

Protein Synonyms/Alias

  

Gene Name

 Zyx 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
24	PAFYAPQKKFAPVVA	acetylation	[1, 2, 3]
25	AFYAPQKKFAPVVAP	acetylation	[1]
35	PVVAPKPKVNPFRPG	acetylation	[3]
256	QAPTPAPKFAPVAPK	acetylation	[3]
263	KFAPVAPKFTPVVSK	acetylation	[1, 2, 3]
270	KFTPVVSKFSPGAPS	acetylation	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). 

Sequence Annotation

 DOMAIN 376 435 LIM zinc-binding 1.
 DOMAIN 436 495 LIM zinc-binding 2.
 DOMAIN 496 562 LIM zinc-binding 3.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 144 144 Phosphoserine.
 MOD_RES 160 160 Phosphothreonine.
 MOD_RES 170 170 Phosphoserine (By similarity).
 MOD_RES 180 180 Phosphothreonine (By similarity).
 MOD_RES 265 265 Phosphothreonine (By similarity).
 MOD_RES 270 270 N6-acetyllysine (By similarity).
 MOD_RES 272 272 Phosphoserine (By similarity).
 MOD_RES 300 300 Phosphoserine (By similarity).
 MOD_RES 336 336 Phosphoserine.  

Keyword

 Acetylation; Cell adhesion; Cell junction; Complete proteome; Cytoplasm; Cytoskeleton; LIM domain; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 564 AA 

Protein Sequence

Gene Ontology

 GO:0005913; C:cell-cell adherens junction; ISO:MGI.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0001725; C:stress fiber; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW. 

Interpro

 IPR001781; Znf_LIM. 

Pfam

 PF00412; LIM 

SMART

 SM00132; LIM 

PROSITE

 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2 

PRINTS