UniProt Accession

 PVRL1_MOUSE; Q9JKF6; Q6P9M9; Q9ERL5; Q9JI17 

Genbank Protein ID

 AF239762; AF270977; AF297665; BC060694 

Genbank Nucleotide ID

 AAF60333.1; AAF76195.1; AAG22808.1; AAH60694.1 

Protein Name

 Poliovirus receptor-related protein 1 

Protein Synonyms/Alias

 Herpes virus entry mediator C; Herpesvirus entry mediator C; HveC; Nectin-1; CD111 

Gene Name

 Pvrl1 

Gene Synonyms/Alias

 Hvec; Prr1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
426	DDSDDEKKAGPLGGS	ubiquitination	[1]
463	PKYDEDAKRPYFTVD	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Probably involved in cell adhesion. Receptor for alphaherpesvirus (HSV-1, HSV-2 and pseudorabies virus) entry into cells. 

Sequence Annotation

 DOMAIN 31 141 Ig-like V-type.
 DOMAIN 145 243 Ig-like C2-type 1.
 DOMAIN 247 334 Ig-like C2-type 2.
 MOD_RES 421 421 Phosphoserine.
 MOD_RES 433 433 Phosphoserine.
 MOD_RES 434 434 Phosphoserine.
 CARBOHYD 36 36 N-linked (GlcNAc...) (Potential).
 CARBOHYD 72 72 N-linked (GlcNAc...) (Potential).
 CARBOHYD 139 139 N-linked (GlcNAc...) (Potential).
 CARBOHYD 200 200 N-linked (GlcNAc...); atypical.
 CARBOHYD 202 202 N-linked (GlcNAc...).
 CARBOHYD 274 274 N-linked (GlcNAc...); atypical.
 CARBOHYD 286 286 N-linked (GlcNAc...).
 CARBOHYD 297 297 N-linked (GlcNAc...) (Potential).
 CARBOHYD 332 332 N-linked (GlcNAc...).
 DISULFID 51 124 By similarity.
 DISULFID 172 226 By similarity.
 DISULFID 269 316 By similarity.  

Keyword

 Cell adhesion; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Host-virus interaction; Immunoglobulin domain; Membrane; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 515 AA 

Protein Sequence

Gene Ontology

 GO:0005913; C:cell-cell adherens junction; IDA:MGI.
 GO:0016021; C:integral to membrane; ISA:MGI.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0042803; F:protein homodimerization activity; IDA:HGNC.
 GO:0004872; F:receptor activity; IDA:MGI.
 GO:0002934; P:desmosome organization; IMP:MGI.
 GO:0070166; P:enamel mineralization; IMP:MGI.
 GO:0007157; P:heterophilic cell-cell adhesion; IDA:HGNC.
 GO:0007156; P:homophilic cell adhesion; IDA:HGNC.
 GO:0006826; P:iron ion transport; IMP:MGI.
 GO:0002089; P:lens morphogenesis in camera-type eye; IMP:MGI.
 GO:0060041; P:retina development in camera-type eye; IMP:MGI.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR013162; CD80_C2-set.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR013106; Ig_V-set. 

Pfam

 PF08205; C2-set_2
 PF07686; V-set 

SMART

 SM00409; IG 

PROSITE

 PS50835; IG_LIKE 

PRINTS