CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033878
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Citron Rho-interacting kinase 
Protein Synonyms/Alias
  
Gene Name
 Cit 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1149LALQQALKEQKLKAEubiquitination[1]
1684YIIKDLEKLLMIAGEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2070 AA 
Protein Sequence
MLKFKYGVRN PPEASASEPI ASRASRLNLF FQGKPPLMTQ QQMSALSREG MLDALFALFE 60
ECSQPALMKM KHVSSFVQKY SDTIAELREL QPSARDFEVR SLVGCGHFAE VQVVREKATG 120
DVYAMKIMKK KALLAQEQVS FFEEERNILS RSTSPWIPQL QYAFQDKNNL YLVMEYQPGG 180
DLLSLLNRYE DQLDESMIQF YLAELILAVH SVHQMGYVHR DIKPENILID RTGHIKLVDF 240
GSAAKMNSNK VDAKLPIGTP DYMAPEVLTV MNEDRRGTYG LDCDWWSVGV VAYEMVYGKT 300
PFTEGTSART FNNIMNFQRF LKFPDDPKVS SELLDLLQSL LCVQKERLKF EGLCCHPFFA 360
RTDWNNIRNS PPPFVPTLKS DDDTSNFDEP EKNSWVSSSV CQLSPSGFSG EELPFVGFSY 420
SKALGYLGRS ESVVSSLDSP AKVSSMEKKL LIKSKELQDS QDKCHKMEQE MTRLHRRVSE 480
VEAVLSQKEV ELKASETQRS LLEQDLATYI TECSSLKRSL EQARMEVSQE DDKALQLLHD 540
IREQSRKLQE IKEQEYQAQV EEMRLMMNQL EEDLVSARRR SDLYESELRE SRLAAEEFKR 600
KANECQHKLM KAKDQGKPEV GEYSKLEKIN AEQQLKIQEL QEKLEKAVKA STEATELLQN 660
IRQAKERAER ELEKLHNRED SSEGIKKKLV EAEERRHSLE NKVKRLETME RRENRLKDDI 720
QTKSEQIQQM ADKILELEEK HREAQVSAQH LEVHLKQKEQ HYEEKIKVLD NQIKKDLADK 780
ESLENMMQRH EEEAHEKGKI LSEQKAMINA MDSKIRSLEQ RIVELSEANK LAANSSLFTQ 840
RNMKAQEEMI SELRQQKFYL ETQAGKLEAQ NRKLEEQLEK ISHQDHSDKS RLLELETRLR 900
EVSLEHEEQK LELKRQLTEL QLSLQERESQ LTALQAARAA LESQLRQAKT ELEETTAEAE 960
EEIQALTAHR DEIQRKFDAL RNSCTVITDL EEQLNQLTED NAELNNQNFY LSKQLDEASG 1020
ANDEIVQLRS EVDHLRREIT EREMQLTSQK QTMEALKTTC TMLEEQVLDL EALNDELLEK 1080
ERQWEAWRSV LGDEKSQFEC RVRELQRMLD TEKQSRARAD QRITESRQVV ELAVKEHKAE 1140
ILALQQALKE QKLKAESLSD KLNDLEKKHA MLEMNARSLQ QKLETERELK QRLLEEQAKL 1200
QQQMDLQKNH IFRLTQGLQE ALDRADLLKT ERSDLEYQLE NIQVLYSHEK VKMEGTISQQ 1260
TKLIDFLQAK MDQPAKKKKG LFSRRKEDPA LPTQVPLQYN ELKLALEKEK ARCAELEEAL 1320
QKTRIELRSA REEAAHRKAT DHPHPSTPAT ARQQIAMSAI VRSPEHQPSA MSLLAPPSSR 1380
RKESSTPEEF SRRLKERMHH NIPHRFNVGL NMRATKCAVC LDTVHFGRQA SKCLECQVMC 1440
HPKCSTCLPA TCGLPAEYAT HFTEAFCRDK MNSPGLQSKE PGSSLHLEGW MKVPRNNKRG 1500
QQGWDRKYIV LEGSKVLIYD NEAREAGQRP VEEFELCLPD GDVSIHGAVG ASELANTAKA 1560
DVPYILKMES HPHTTCWPGR TLYLLAPSFP DKQRWVTALE SVVAGGRVSR EKAEADAKLL 1620
GNSLLKLEGD DRLDMNCTLP FSDQVVLVGT EEGLYALNVL KNSLTHIPGI GAVFQIYIIK 1680
DLEKLLMIAG EERALCLVDV KKVKQSLAQS HLPAQPDVSP NIFEAVKGCH LFAAGKIENS 1740
LCICAAMPSK VVILRYNDNL SKYCIRKEIE TSEPCSCIHF TNYSILIGTN KFYEIDMKQY 1800
TLDEFLDKND HSLAPAVFAS SSNSFPVSIV QANSAGQREE YLLCFHEFGV FVDSYGRRSR 1860
TDDLKWSRLP LAFAYREPYL FVTHFNSLEV IEIQARSSLG SPARAYLEIP NPRYLGPAIS 1920
SGAIYLASSY QDKLRVICCK GNLVKESGTE QHRVPSTSRS SPNKRGPPTY NEHITKRVAS 1980
SPAPPEGPSH PREPSTPHRY RDREGRTELR RDKSPGRPLE REKSPGRMLS TRRERSPGRL 2040
FEDSSRGRLP AGAVRTPLSQ VNKVWDQSSV 2070 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IDA:MGI.
 GO:0001726; C:ruffle; IDA:MGI.
 GO:0005773; C:vacuole; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0004674; F:protein serine/threonine kinase activity; IDA:MGI.
 GO:0005083; F:small GTPase regulator activity; IEA:InterPro.
 GO:0000910; P:cytokinesis; IMP:MGI.
 GO:0016358; P:dendrite development; IMP:MGI.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0007091; P:metaphase/anaphase transition of mitotic cell cycle; IMP:MGI.
 GO:0000070; P:mitotic sister chromatid segregation; IMP:MGI.
 GO:0050774; P:negative regulation of dendrite morphogenesis; IDA:MGI.
 GO:0045665; P:negative regulation of neuron differentiation; ISO:MGI.
 GO:0007283; P:spermatogenesis; IMP:MGI. 
Interpro
 IPR000961; AGC-kinase_C.
 IPR001180; Citron.
 IPR017405; Citron_Rho-interacting_kinase.
 IPR011009; Kinase-like_dom.
 IPR011993; PH_like_dom.
 IPR017892; Pkinase_C.
 IPR001849; Pleckstrin_homology.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00780; CNH
 PF00069; Pkinase
 PF00433; Pkinase_C 
SMART
 SM00109; C1
 SM00036; CNH
 SM00233; PH
 SM00133; S_TK_X
 SM00220; S_TKc 
PROSITE
 PS51285; AGC_KINASE_CTER
 PS50219; CNH
 PS50003; PH_DOMAIN
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST
 PS00479; ZF_DAG_PE_1
 PS50081; ZF_DAG_PE_2 
PRINTS