| Tag | Content |
|---|
| CPLM ID | CPLM-004457 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Potassium voltage-gated channel subfamily A member 1 |
Protein Synonyms/Alias | MBK1; MKI; Voltage-gated potassium channel subunit Kv1.1 |
Gene Name | Kcna1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 53 | LRFETQLKTLAQFPN | ubiquitination | [1] | | 67 | NTLLGNPKKRMRYFD | ubiquitination | [1] | | 129 | LGEEAMEKFREDEGF | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. |
Sequence Annotation | MOTIF 372 377 Selectivity filter (By similarity).
MOTIF 493 495 PDZ-binding (By similarity).
MOD_RES 322 322 Phosphoserine; by PKA (Potential).
MOD_RES 446 446 Phosphoserine; by PKA (Potential).
LIPID 243 243 S-palmitoyl cysteine (By similarity).
CARBOHYD 207 207 N-linked (GlcNAc...) (Potential). |
Keyword | Complete proteome; Glycoprotein; Ion channel; Ion transport; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Potassium; Potassium channel; Potassium transport; Reference proteome; RNA editing; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 495 AA |
Protein Sequence | MTVMSGENAD EASTAPGHPQ DGSYPRQADH DDHECCERVV INISGLRFET QLKTLAQFPN 60
TLLGNPKKRM RYFDPLRNEY FFDRNRPSFD AILYYYQSGG RLRRPVNVPL DMFSEEIKFY 120
ELGEEAMEKF REDEGFIKEE ERPLPEKEYQ RQVWLLFEYP ESSGPARVIA IVSVMVILIS 180
IVIFCLETLP ELKDDKDFTG TIHRIDNTTV IYTSNIFTDP FFIVETLCII WFSFELVVRF 240
FACPSKTDFF KNIMNFIDIV AIIPYFITLG TEIAEQEGNQ KGEQATSLAI LRVIRLVRVF 300
RIFKLSRHSK GLQILGQTLK ASMRELGLLI FFLFIGVILF SSAVYFAEAE EAESHFSSIP 360
DAFWWAVVSM TTVGYGDMYP VTIGGKIVGS LCAIAGVLTI ALPVPVIVSN FNYFYHRETE 420
GEEQAQLLHV SSPNLASDSD LSRRSSSTIS KSEYMEIEED MNNSIAHYRQ ANIRTGNCTT 480
ADQNCVNKSK LLTDV 495 |
Gene Ontology | GO:0016324; C:apical plasma membrane; IEA:Compara. GO:0030425; C:dendrite; IEA:Compara. GO:0044224; C:juxtaparanode region of axon; IDA:BHF-UCL. GO:0043025; C:neuronal cell body; IEA:Compara. GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro. GO:0005251; F:delayed rectifier potassium channel activity; IBA:RefGenome. GO:0051260; P:protein homooligomerization; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |