UniProt Accession

 D3YXX3_MOUSE; D3YXX3 

Genbank Protein ID

 AC124373 

Genbank Nucleotide ID

  

Protein Name

 RAC-alpha serine/threonine-protein kinase 

Protein Synonyms/Alias

  

Gene Name

 Akt1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
30	RPRYFLLKNDGTFIG	ubiquitination	[1]
179	TGRYYAMKILKKEVI	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

  

Sequence Annotation

  

Keyword

 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 202 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0005819; C:spindle; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0030235; F:nitric-oxide synthase regulator activity; IEA:Compara.
 GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:Compara.
 GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; IEA:Compara.
 GO:0004672; F:protein kinase activity; IDA:MGI.
 GO:0006924; P:activation-induced cell death of T cells; ISO:MGI.
 GO:0007568; P:aging; IEA:Compara.
 GO:0042640; P:anagen; IMP:MGI.
 GO:0008637; P:apoptotic mitochondrial changes; IDA:MGI.
 GO:0030030; P:cell projection organization; ISO:MGI.
 GO:0071363; P:cellular response to growth factor stimulus; IDA:MGI.
 GO:0071456; P:cellular response to hypoxia; IEA:Compara.
 GO:0032869; P:cellular response to insulin stimulus; IDA:MGI.
 GO:0097194; P:execution phase of apoptosis; IDA:MGI.
 GO:0007281; P:germ cell development; IDA:MGI.
 GO:0042593; P:glucose homeostasis; IMP:MGI.
 GO:0006006; P:glucose metabolic process; IMP:MGI.
 GO:0005978; P:glycogen biosynthetic process; IEA:Compara.
 GO:0060709; P:glycogen cell differentiation involved in embryonic placenta development; IMP:MGI.
 GO:0005977; P:glycogen metabolic process; IMP:MGI.
 GO:0006954; P:inflammatory response; IDA:MGI.
 GO:0008286; P:insulin receptor signaling pathway; IEA:Compara.
 GO:0048009; P:insulin-like growth factor receptor signaling pathway; IEA:Compara.
 GO:0060716; P:labyrinthine layer blood vessel development; IMP:MGI.
 GO:0001893; P:maternal placenta development; IMP:MGI.
 GO:0045792; P:negative regulation of cell size; ISO:MGI.
 GO:0031999; P:negative regulation of fatty acid beta-oxidation; IEA:Compara.
 GO:0046329; P:negative regulation of JNK cascade; IEA:Compara.
 GO:0010748; P:negative regulation of plasma membrane long-chain fatty acid transport; IEA:Compara.
 GO:0006469; P:negative regulation of protein kinase activity; IEA:Compara.
 GO:0001649; P:osteoblast differentiation; IGI:MGI.
 GO:0018105; P:peptidyl-serine phosphorylation; IDA:MGI.
 GO:0032287; P:peripheral nervous system myelin maintenance; IMP:MGI.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0043536; P:positive regulation of blood vessel endothelial cell migration; IEA:Compara.
 GO:0030307; P:positive regulation of cell growth; IEA:Compara.
 GO:0031659; P:positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; IEA:Compara.
 GO:0090004; P:positive regulation of establishment of protein localization to plasma membrane; IEA:Compara.
 GO:0045600; P:positive regulation of fat cell differentiation; IEA:Compara.
 GO:0046326; P:positive regulation of glucose import; IEA:Compara.
 GO:0045725; P:positive regulation of glycogen biosynthetic process; IEA:Compara.
 GO:0046889; P:positive regulation of lipid biosynthetic process; IEA:Compara.
 GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Compara.
 GO:0051000; P:positive regulation of nitric-oxide synthase activity; IEA:Compara.
 GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Compara.
 GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IMP:MGI.
 GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0010765; P:positive regulation of sodium ion transport; IMP:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:MGI.
 GO:0045907; P:positive regulation of vasoconstriction; IEA:Compara.
 GO:0030163; P:protein catabolic process; IDA:MGI.
 GO:0000060; P:protein import into nucleus, translocation; IEA:Compara.
 GO:0043491; P:protein kinase B signaling cascade; IGI:MGI.
 GO:0016567; P:protein ubiquitination; IDA:MGI.
 GO:0032880; P:regulation of protein localization; IDA:MGI.
 GO:0034405; P:response to fluid shear stress; IEA:Compara.
 GO:0032094; P:response to food; IDA:MGI.
 GO:0070141; P:response to UV-A; IEA:Compara.
 GO:0051146; P:striated muscle cell differentiation; IGI:MGI.
 GO:0006412; P:translation; IEA:Compara. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS. 

Pfam

 PF00169; PH
 PF00069; Pkinase 

SMART

 SM00233; PH 

PROSITE

 PS50003; PH_DOMAIN
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM 

PRINTS