UniProt Accession

 KCAB3_HUMAN; O43448; Q4VAW0 

Genbank Protein ID

 AF016411; BC096232; BC096234; BC099634 

Genbank Nucleotide ID

 AAB92499.1; AAH96232.1; AAH96234.1; AAH99634.1 

Protein Name

 Voltage-gated potassium channel subunit beta-3 

Protein Synonyms/Alias

 K(+) channel subunit beta-3; Kv-beta-3 

Gene Name

 KCNAB3 

Gene Synonyms/Alias

 KCNA3B 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
85	MKYRNLGKSGLRVSC	ubiquitination	[1]
175	TERGLSRKHIIEGLR	ubiquitination	[1]
315	IKGYQWLKDKVQSED	acetylation	[2]
315	IKGYQWLKDKVQSED	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5. 

Sequence Annotation

  

Keyword

 Complete proteome; Cytoplasm; Ion channel; Ion transport; Potassium; Potassium transport; Reference proteome; Transport; Voltage-gated channel. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 404 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0015459; F:potassium channel regulator activity; TAS:ProtInc.
 GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
 GO:0006813; P:potassium ion transport; TAS:ProtInc.
 GO:0007268; P:synaptic transmission; TAS:Reactome. 

Interpro

 IPR001395; Aldo/ket_red.
 IPR005983; K_chnl_volt-dep_bsu_KCNAB.
 IPR005399; K_chnl_volt-dep_bsu_KCNAB-rel.
 IPR005402; K_chnl_volt-dep_bsu_KCNAB3.
 IPR023210; NADP_OxRdtase_dom. 

Pfam

 PF00248; Aldo_ket_red 

SMART

  

PROSITE

  

PRINTS

 PR01580; KCNAB3CHANEL.
 PR01577; KCNABCHANNEL.