CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032184
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Hypoxia up-regulated protein 1 
Protein Synonyms/Alias
 cDNA FLJ54708, highly similar to 150 kDa oxygen-regulated protein (Orp150) 
Gene Name
 HYOU1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
19YFQHLLGKQADNPHVubiquitination[1]
221ENPRAMAKLLREANRubiquitination[1]
311RVQEVLLKAVGKEELubiquitination[2]
315VLLKAVGKEELGKNIubiquitination[1]
376EPGIHSLKHNKRVLFubiquitination[1]
433SQNLTTVKLKGVGDSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 559 AA 
Protein Sequence
MAIKNPKATL RYFQHLLGKQ ADNPHVALYQ ARFPEHELTF DPQRQTVHFQ ISSQLQFSPE 60
EVLGMVLNYS RSLAEDFAEQ PIKDAVITVP VFFNQAERRA VLQAARMAGL KVLQLINDNT 120
ATALSYGVFR RKDINTTAQN IMFYDMGSGS TVCTIVTYQM VKTKEAGMQP QLQIRGVGFD 180
RTLGGLEMEL RLRERLAGLF NEQRKGQRAK DVRENPRAMA KLLREANRLK TVLSANADHM 240
AQIEGLMDDV DFKAKVTRVE FEELCADLFE RVPGPVQQAL QSAEMSLDEI EQVILVGGAT 300
RVPRVQEVLL KAVGKEELGK NINADEAAAM GAVYQAAALS KAFKVKPFVV RDAVVYPILV 360
EFTREVEEEP GIHSLKHNKR VLFSRMGPYP QRKVITFNRY SHDFNFHINY GDLGFLGPED 420
LRVFGSQNLT TVKLKGVGDS FKKYPDYESK GIKAHFNLDE SGVLSLDRVE SVFETLVEDS 480
AEEESTLTKL GNTISSLFGG GTTPDAKENG TDTVQMLFLC PARLPQSKQA IDRFHTAVTC 540
MEPPWGRRCR ARPAWRLCS 559 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW. 
Interpro
 IPR018181; Heat_shock_70_CS.
 IPR013126; Hsp_70_fam. 
Pfam
 PF00012; HSP70 
SMART
  
PROSITE
 PS00329; HSP70_2
 PS01036; HSP70_3 
PRINTS
 PR00301; HEATSHOCK70.