CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029480
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Diacylglycerol kinase zeta 
Protein Synonyms/Alias
  
Gene Name
 DGKZ 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
114PCIEQLEKINFRCKPubiquitination[1]
337TLDQLRLKPPPPVAIubiquitination[1, 2]
440SREANPEKFNSRFRNubiquitination[1, 2]
469GSSKDLAKHIRVVCDubiquitination[1]
488TPKIQDLKPQCVVFLubiquitination[1]
572QVDGEPCKLAASRIRubiquitination[1]
671EPDGAGAKSPTCQKLubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 ANK repeat; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 895 AA 
Protein Sequence
MWRYRSWDVP QIPSEAPQTQ KAITKSGLQH LAPPPPTPGA PCSESERQIR STVDWSESAT 60
YGEHIWFETN VSGDFCYVGE QYCVARMLQK SVSRRKCAAC KIVVHTPCIE QLEKINFRCK 120
PSFRESGSRN VREPTFVRHH WVHRRRQDGK CRHCGKGFQQ KFTFHSKEIV AISCSWCKQA 180
YHSKVSCFML QQIEEPCSLG VHAAVVIPPT WILRARRPQN TLKASKKKKR ASFKRKSSKK 240
GPEEGRWRPF IIRPTPSPLM KPLLVFVNPK SGGNQGAKII QSFLWYLNPR QVFDLSQGGP 300
KEALEMYRKV HNLRILACGG DGTVGWILST LDQLRLKPPP PVAILPLGTG NDLARTLNWG 360
GGYTDEPVSK ILSHVEEGNV VQLDRWDLHA EPNPEAGPED RDEGATDRLP LDVFNNYFSL 420
GFDAHVTLEF HESREANPEK FNSRFRNKMF YAGTAFSDFL MGSSKDLAKH IRVVCDGMDL 480
TPKIQDLKPQ CVVFLNIPRY CAGTMPWGHP GEHHDFEPQR HDDGYLEVIG FTMTSLAALQ 540
VGGHGERLTQ CREVVLTTSK AIPVQVDGEP CKLAASRIRI ALRNQATMVQ KAKRRSAAPL 600
HSDQQPVPEQ LRIQVSRVSM HDYEALHYDK EQLKEASVPL GTVVVPGDSD LELCRAHIER 660
LQQEPDGAGA KSPTCQKLSP KWCFLDATTA SRFYRIDRAQ EHLNYVTEIA QDEIYILDPE 720
LLGASARPDL PTPTSPLPTS PCSPTPRSLQ GDAAPPQGEE LIEAAKRNDF CKLQELHRAG 780
GDLMHRDEQS RTLLHHAVST GSKDVVRYLL DHAPPEILDA VEENGETCLH QAAALGQRTI 840
CHYIVEAGAS LMKTDQQGDT PRQRAEKAQD TELAAYLENR QHYQMIQRED QETAV 895 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0004143; F:diacylglycerol kinase activity; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0007205; P:protein kinase C-activating G-protein coupled receptor signaling pathway; IEA:InterPro. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR000756; Diacylglycerol_kin_accessory.
 IPR001206; Diacylglycerol_kinase_cat_dom.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd. 
Pfam
 PF00130; C1_1
 PF00609; DAGK_acc
 PF00781; DAGK_cat 
SMART
 SM00248; ANK
 SM00109; C1
 SM00045; DAGKa
 SM00046; DAGKc 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS50146; DAGK 
PRINTS